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Regulatory Effect of Atopic Allergic Reaction by Modified Gagam-danguieumja  

Na, Ho-Jeong (College of Oriental Pharmacy, Wonkwang University, College of Oriental Medicine, Kyung Hee University)
Kwon, Dong-Yeul (College of Oriental Pharmacy, Wonkwang University)
Kim, Hyung-Min (College of Oriental Medicine, Kyung Hee University)
Park, Eun-Jeong (College of Oriental Medicine, Wonkwang University)
Lee, Eun-Hee (Division of Beauty Arts, Jeonbuk Science College)
Hong, Seung-Heon (College of Oriental Pharmacy, Wonkwang University)
Publication Information
Biomolecules & Therapeutics / v.12, no.4, 2004 , pp. 235-241 More about this Journal
Abstract
Gagam-danguiemja (GDGJ), a traditional Korean prescription, has been used as therapeutics for atopic allergic diseases such as atopic dermatitis. To evaluate the atopic allergic effect of modified GDGJ, we investigated a possible effect of GDGJ on mast cell-mediated allergic reaction, cytokinases secretion and mRNA expression in vivo and in vitro. Mast cells are a potent source of mediators that regulate the inflammatory response in allergic reaction. In mice orally administered by GDGJ (0.01, 0.1 and 1.0 g/kg) for 1 h, compound 48/80-induced ear oedema was significantly reduced. TNF-${\alpha}$, IL-8, and IL-6 secretion were inhibited by GDGJ in the human mast cell line (HNC-1). But TNF-${\alpha}$, IL-8, and IL-6 mRNA expression were not inhibited by GDGJ at the dose of 0.01 mg/ml. These findings may help in understanding the mechanism of action of this herbal medication, leading to the control of mast cells in atopic allergic reaction like AD.
Keywords
Gagam-danguiemja; atopic allergic reactions; mast cell; cytokine;
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