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Reduction of Photodamage by TopicaI Application of a Novel Anti-Wrinkle Agent Containing Growth Factors  

Kim, Ju-Mi (Research Laboratories, Dong-A Pharm. Co. Ltd.)
Ahn, Gook-Jun (Research Laboratories, Dong-A Pharm. Co. Ltd.)
Sohn, Young-Sung (Research Laboratories, Dong-A Pharm. Co. Ltd.)
Kang, Kyung-Koo (Research Laboratories, Dong-A Pharm. Co. Ltd.)
Ahn, Byoung-Ok (Research Laboratories, Dong-A Pharm. Co. Ltd.)
Lee, Jung-Hwan (Research Laboratories, Dong-A Pharm. Co. Ltd.)
Kim, Byung-Moon (Research Laboratories, Dong-A Pharm. Co. Ltd.)
Kwon, Jong-Won (Research Laboratories, Dong-A Pharm. Co. Ltd.)
Kim, Won-Bae (Research Laboratories, Dong-A Pharm. Co. Ltd.)
Publication Information
Biomolecules & Therapeutics / v.12, no.3, 2004 , pp. 157-164 More about this Journal
Abstract
DA-3711 is a novel anti-wrinkle agent containing growth factors derived from culture medium of artificial human skin. Photoprotective effect by DA-3711 against chronic UVB (ultraviolet B)-induced skin damage was investigated in hairless mice model. Methods: After hairless mice were irradiated to induce photodamage for 8 weeks with UVB, grouped mice were treated topically once a day with lotion base, DA-3711 (30% or l5%), Cylasphere retinol$^{\circed{R}}$ (2500 I.U.), NouriCel$^{\circed{R}}$ along with concomitant exposure to UVB for further 8 weeks. Then mice were sacrificed to assess photodamage-protective effect by replica analysis, biochemistry and histology. DA-3711 of 30% lotion significantly reduced UVB radiation-induced wrinkling, histological alterations and increased collagen contents. Whereas DA-3711 of l5% lotion and NouriCel$^{\circed{R}}$ treatment showed a partial protective effect on skin wrinkle, epidermal and dermal thickness, and collagen content, Cylasphere retinol$^{\circed{R}}$ showed no protective effects. These results demonstrate that topical application of DA-3711 can alleviate UVB-induced photodamage and potentially be used for reduction of UVB-induced photodamage.
Keywords
DA-3711; growth factors; hairless mice; photodamage; ultraviolet B;
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