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Effect of Hwangryunhaedoktang on Contact Hypersensitivity and Passive Cutaneous Hypersensitivity in Mice  

Lee, Kun-Ho (College of Pharmacy, Kyung Hee University)
Shin, Young-Wook (East-West Pharmaceutical Research Institute, Kyung Hee University)
Kim, Dong-Hyung (College of Pharmacy and East-West Pharmaceutical Research Institute, Kyung Hee University)
Publication Information
Biomolecules & Therapeutics / v.12, no.2, 2004 , pp. 129-132 More about this Journal
Abstract
During the screening program to discover antiatopic agents from herbal formulas, we investigated the inhibitory effect of Hwangryunhaedoktang (HT) on passive cutaneous anaphylaxis and oxazolone-induced mouse ear dermatitis. HT significantly inhibited PCA reaction in mice at doses of 50 and 200 mg/kg with inhibitory activity of 31 and 53%, respectively. HT at concentration of 0.05 and 0.1% inhibited ear swelling by 23 and 46% at 16 days in oxazolone-induced mouse ear dermatitis. Both HT with anti without human intestinal microflora showed potent inhibitory activity on the ${\beta}$-hexosaminidase release induced by IgE. Based on these findings, HT may be a usable agent for skin disorder contact dermatitis.
Keywords
hwangryunhaedoktang; psoriasis; passive cutaneous anaphylaxis; oxazolone-induced dermatitis;
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