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Immunodulatory Activity of Triterpenes and Phenolic Compounds from Viscum Album L.  

박대섭 (성균관대학교 약학대학)
최상진 (성균관대학교 약학대학)
김경란 (성균관대학교 약학대학)
이선미 (성균관대학교 약학대학)
이강노 (성균관대학교 약학대학)
표석능 (성균관대학교 약학대학)
Publication Information
Biomolecules & Therapeutics / v.11, no.1, 2003 , pp. 1-4 More about this Journal
Abstract
Plants are known as important source in the search for new drugs. The twelve compounds from Viscum album (Loranthaceae), lupeol (1), betulonic acid (2), betulinic acid (3), terminic acid (4), ursolic acid (5), $\beta$-sitosterol (6), $\alpha$-spinasterol (7), oleanolic acid (8), 5-hydroxy-1-(4′-hydoxyphenyl)-7-(4"-hydroxyphenyl)-hepta-1-en-3-on (9), 2′-hydroxy-4′,6′-dimethoxychalcone-4-O-glucoside (10), 2′-hydroxy-4′,6′-dimethoxychalcone-4-O-[apiosyl(l$\longrightarrow$2)]glucoside (11) and syringin (12) were evaluated for their immunomodulatory properties. Compounds 6 and 11 induced the macrophage tumoricidal activity and the lymphocyte blastogenesis. In addition, these compounds stimulated the macrophages to induce the production of TNF-$\alpha$ and NO. These findings suggest that compounds 6 and 11 are modulating various elements of the host immune response.
Keywords
Viscum album L.; T and B lymphocyte; macrophage; TNF-$\alpha$; NO;
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