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Studies on the Correlation between SPF Index and Skin Irritation Index of Sunscreens  

김종원 (식품의약품안전청 국립독성연구원 안전성평가과)
서수경 (식품의약품안전청 국립독성연구원 안전성평가과)
최주영 (식품의약품안전청 국립독성연구원 안전성평가과)
박창원 (식품의약품안전청 국립독성연구원 안전성평가과)
서경원 (식품의약품안전청 국립독성연구원 안전성평가과)
김규봉 (식품의약품안전청 국립독성연구원 안전성평가과)
김광진 (식품의약품안전청 국립독성연구원 안전성평가과)
김재희 (식품의약품안전청 국립독성연구원 안전성평가과)
이선희 (식품의약품안전청 국립독성연구원 안전성평가과)
Publication Information
Biomolecules & Therapeutics / v.10, no.4, 2002 , pp. 246-252 More about this Journal
Abstract
In recent years, the safety of sunscreens has been challenged based on the reports of their adverse effect on users; dermatitis, allergic contact dermatitis and photo allergic contact dermatitis. The unscientific idea that higher SPF sunsreen is good for health mealeads many users to tend to prefer higher SPF sunscreen. In the toxicological aspect, the need to investigate the safety of sunscreens is steadily increasing. However, there were few studies on the correlation between sun protection factor (SPF) and the safety of sunscreens. The objective of this study was to assess whether there was a correlation between SPF and the safety of sunscreens. We measured in vitro SPF index using homosalate as a standard and examined the toxicity tests such as primary skin irritation tests, ocular irritation test and skin sensitization test. Homosalate (HS), octyl methoxycinnamate (OMC), octyl salicylate (OS), octocrylene (OC) as UVB organic filter and benzophenone-3 (BP3), butyl methoxy dibenzoil methane (BMDM) as UVA organic filter, and titanium dioxide (TD), zinc oxide (ZO) as inorganic filters were used. The skin irritation indexes in rabbits treated with HS, OMC, OS, BP3, and BMDM were significantly increased as SPF indices were increased. Neither ocular irritation in rabbits nor skin sensitization in guinea pigs were increased. It suggests that there might be a good correlation between SPF and the skin irritation indices of organic UV filters and skin irritation might be one of most sensitive index to assess the safety of sunscreens.
Keywords
sunscreens; SPF index; cosmetic safety; organic filters; skin irritation;
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