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Curcuma Extract Enhances Hepatoprotective Action of Silymarin in Experimental Liver Damage Models  

이기명 (아주대학교 의과대학 소화기내과)
함기백 (아주대학교 의과대학 소화기내과)
조성원 (아주대학교 의과대학 소화기내과)
오태영 (동아제약(주) 연구소)
최설민 (동아제약(주) 연구소)
김정훈 (동아제약(주) 연구소)
안병옥 (동아제약(주) 연구소)
권종원 (동아제약(주) 연구소)
김원배 (동아제약(주) 연구소)
Publication Information
Biomolecules & Therapeutics / v.10, no.1, 2002 , pp. 12-18 More about this Journal
Silymarin and curcumin have been used for supportive treatment of liver disease of difffrent etiology due to their hepatoprotective activities. The present study was carried out to investigate the hepatoprotective efffcts of silymarin and/or curcuma extract against hepatotoxins induced liver injury. To investigate hepatoprotective effects, the silymarin and/or curcuma extract were pre-treated orally to experimental animals. And thereafter a single dose of hepatotoxin, carbon tetrachloride ($CCl_4$) and acetaminophen were administered through oral or intraperitoneal route, respectively. Chronic liver damage was induced by subcutaneous injection of $CCl_4$ for 3 weeks (2 times/week). Hepatoprotective and therapeutic effects were monitored by estimating serurn ALT and AST levels and by measuring hepatic glutathione (GSH) and malondialdehyde (MDA)levels. Collagen type 1 was detected with irnrnunostaining to assess fibrosis. The results showed that the mix-ture of silymarin and curcuma extract significantly reduced serum biochemistry levels and MDA levels com-pared with those of control group in both acute and chronic animal models. In antifibrotic effect, the relative hepatic collagen content was significantly decreased by silymarin and/or curcuma extract treatment. It was concluded that the complex of silymarin and curcuma extract have a both hepatoprotective and therapeutic effect synergically in rat liver injury induced by heptotoxins.
Acetaminophen; acute/chronic liver damage; curcuma extract; carbon tetrachloride; silymarin;
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