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USE OF CORTICOSTEROIDS IN THE TREATMENT OF LOCALIZED LANGERHANS CELL HISTIOCYTOSIS OF THE MANDIBLE : CASE REPORT  

Choi, Jung-Yong (Department of Oral Maxillofacial Surgery. St. Mary's Hospital. The Catholic University of Korea)
Lee, Sang-Hwa (Department of Oral Maxillofacial Surgery. St. Mary's Hospital. The Catholic University of Korea)
Yoon, Hyun-Joong (Department of Oral Maxillofacial Surgery. St. Mary's Hospital. The Catholic University of Korea)
Publication Information
Maxillofacial Plastic and Reconstructive Surgery / v.31, no.3, 2009 , pp. 249-253 More about this Journal
Abstract
Langerhans cell histiocytosis(LCH), previously known as histiocytosis X, is rare, proliferative disorder in which the accumulation of pathologic Langerhans cell leads to tissue infiltration and destruction. The jaw is involved 10~20% of all LCH and most common oral symptoms are jaw swelling or a palpation mass. Most of subjects are males and disease appears to start before the age of 10 years. An 11 years old girl was referred from pediatric department. Histological examination confirmed the diagnosis LCH. She was treated intra-lesional injection of corticosteroid. The overall outcome was excellent. After a follow-up period of 20 month, the patient present with no evidence of residual disease on Panoramic view and whole body bone scan. We report this early recognized LCH case treated by corticoid injection in good progress with literature review.
Keywords
Langerhans cell histiocytosis; Eosinophilic granuloma; Corticosteroids; Intralesional injection;
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1 Hartman KS. Histiocytosis X : a review of 114 cases with oral involvement. Oral Surg Oral Med Oral Pathol 49 : 38, 1980   DOI   ScienceOn
2 Cohen M, Zornoza J, Cangir A et al : Direct injection of methylprednisolone sodium succinate in the treatment of solitary eosinophilic granuloma of bone: a report of 9 cases. Radiology 136 : 289, 1980
3 Richter MP, D'Angio GJ : The role of radiation therapy in the management of children with histiocytosis X. Am J Pediatr Hematol Oncol 3 : 161, 1981   DOI   PUBMED
4 Marusic, A, Raisz L : Cortisol modulates the actions of interleukin-1 alpha on bone formation, resorption, and prostaglandin production in cultured mouse parietal bones. Endocrinology 129 : 2699, 1991   DOI   ScienceOn
5 Glotzbecker MP, Carpentieri DF, Dormans JP : Langerhans cell histiocytosis: a primary viral infection of bone? Human herpes virus 6 latent protein detected in lymphocytes from tissue of children. J Pediatr Orthop 24 : 123, 2004   DOI   ScienceOn
6 Haupt R, Nanduri V, Calevo MG et al : Permanent consequences in Langerhans cell histiocytosis patients: a pilot study from the Histiocyte Society-Late Effects Study Group. Pediatr Blood Cancer 42 : 438, 2004   DOI   ScienceOn
7 Ardekian L, Peled M, Rosen D et al : Clinical and radiographic features of eosinophilic granuloma in the jaws: review of 41 lesions treated by surgery and low-dose radiotherapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 87 : 238, 1999   DOI   ScienceOn
8 Jones AV, Franklin CD : An analysis of oral and maxillofacial pathology found in children over a 30-year period. Int J Paediatr Dent 16 : 19, 2006   DOI   ScienceOn
9 khan MA, Kosugi S, Tomizawa M et al : Effects of radiotherapy on dentofacial regions at early age: case report. Pediatric Dental Journal 4 : 83, 1994
10 Egeler RM, Thompson RC Jr, Voute PA et al : Intralesional infiltration of corticosteroids in localized Langerhans'cell histiocytosis. J Pediatr Orthop 12 : 811, 1992   DOI
11 Yu Q, Wang PZ, Shi HM et al : Radiographic findings in Langerhans' cell disease affecting the mandible. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 79 : 251, 1995   DOI   ScienceOn
12 Key SJ, O'Brien CJ, Silvester KC et al : Eosinophilic granuloma: resolution of maxillofacial bony lesions following minimal intervention. Report of three cases and a review of the literature. J Craniomaxillofac Surg 32 : 170, 2004   DOI   ScienceOn
13 Jones LR, Toth BB, Cangir A. Treatment for solitary eosinophilic granuloma of the mandible by steroid injection: report of a case. J Oral Maxillofac Surg 47 : 306, 1989   DOI   ScienceOn
14 Yasko AW, Fanning CV, Ayala AG et al : Percutaneous techniques for the diagnosis and treatment of localized Langerhans-cell histiocytosis (eosinophilic granuloma of bone). J Bone Joint Surg Am 80 : 219, 1998
15 Martinez-Lage JF, Poza M, Cartagena J et al : Solitary eosinophilic granuloma of the pediatric skull and spine. The role of surgery. Childs Nerv Syst 7 : 448. 1991   DOI   ScienceOn
16 Egeler RM, de Kraker J, Voute PA : Cytosine-arabinoside, vincristine, and prednisolone in the treatment of children with disseminated Langerhans cell histiocytosis with organ dysfunction: experience at a single institution. Med Pediatr Oncol 21 : 265, 1993   DOI   ScienceOn
17 Uckan S, Gurol M, Durmus E : Recurrent multifocal Langerhans cell eosinophilic granuloma of the jaws: report of a case. J Oral Maxillofac Surg 54 : 906, 1996   DOI   ScienceOn
18 Stoll m, Freund M, Schmidt H et al : Allogeneic bone marrow transplantation for Langerhans'cell histiocytosis. Cancer 66 : 284, 1990   DOI   ScienceOn
19 Scaglietti O, Marchetti PG, Bartolozzi P : The effects of methylprednisolone acetate in the treatment of bone cysts. Results of three years follow-up. J Bone Joint Surg Br 61 : 200, 1979
20 McClain KL, Natkunam Y, Swerdlow SH : Atypical cellular disorders. Hematology Am Soc Hematol Educ Program 283, 2004