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LANGERHANS CELL HISTIOCYTOSIS IN THE JUVENILE MANDIBLE  

Kang, Yeon-Hee (Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University)
Park, Se-Hyun (Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University)
Seo, Dong-Jun (Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University)
Cha, In-Ho (Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University)
Yi, Choong-Kook (Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University)
Kim, Hyun-Sil (Oral Cancer Research Institute, College of Dentistry, Yonsei University)
Kim, Jin (Department of Oral Pathology, College of Dentistry, Yonsei University)
Kim, Hyung-Jun (Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University)
Publication Information
Maxillofacial Plastic and Reconstructive Surgery / v.30, no.6, 2008 , pp. 577-583 More about this Journal
Abstract
Langerhans cell histiocytosis (LCH) is characterized by proliferation of pathological Langerhans cells within different organs. It mainly affects children, but adult cases also occur, with an incidence rate of one to two per million. LCH results from the clonal proliferation of Langerhans cells. And its etiopathogenesis is still unknown. The hypothesis that it is a neoplastic or inflammatory disease, as well as the existence or not of immunological, viral or genetic predisposing factors, has been widely discussed in the literature, but no conclusive proof has ever been provided. Although lesions may appear in tissues of various origins such as skin, hypothalamus, liver, lung, or lymphoid tissue, bone is the most common site of the disease. The head and neck are affected in almost 90% of cases. The maxillary and mandibular bones are affected in 5 to 10% of cases. In our report, we present four cases of LCH in patients aged 3, 4, 7 and 9 years respectively, with primary manifestation in maxillofacial area.
Keywords
Langerhans cell histiocytosis; Histiocytosis-X; Hand-Schuller-Christian disease; Eosinophilic granuloma; Letterer-Siwe disease;
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