Browse > Article

EFFECT OF PULSED ELECTROMAGNETIC FIELD STIMULATION ON THE EARLY BONE CONSOLIDATION AFTER DISTRACTION OSTEOGENESIS IN RABBIT MANDIBLE MODEL  

Hwang, Kyung-Kyun (Dept. of Oral & Maxillofacial Surgery, College of Medicine, Hanyang University)
Cho, Tae-Hyung (Dental Research Institute, Brain Korea 21 for Dental Life Science, Seoul National University)
Song, Yun-Mi (Dental Research Institute, Brain Korea 21 for Dental Life Science, Seoul National University)
Kim, Do-Kyun (Dept. of Oral & Maxillofacial Surgery, School of Dentistry, Seoul National University)
Han, Sung-Hee (Dept. of Oral & Maxillofacial Surgery, School of Dentistry, Seoul National University)
Kim, In-Sook (Dental Research Institute, Brain Korea 21 for Dental Life Science, Seoul National University)
Hwang, Soon-Jung (Dental Research Institute, Brain Korea 21 for Dental Life Science, Seoul National University)
Publication Information
Maxillofacial Plastic and Reconstructive Surgery / v.29, no.2, 2007 , pp. 123-131 More about this Journal
Abstract
Introduction: Distraction osteogenesis is widely used as for bone lengthening in patients with maxillofacial deformity and alveolar bone atrophy. One of the major problems in distraction osteogenesis is long consolidation period for 2-3 months, in which the devices have to be fixed on the bone to prevent relapse. It results in scar formation on the face, disturbance of mastication and speech. This study was performed to evaluate the stimulating effect of pulsed electromagnetic field on the early bone consolidation in distraction osteogenesis. Materials and methods: Total 10 rabbit were used (5 for control group, 5 for experimental group). A vertical osteotomy in the mandibular body was performed and the distraction device was fixed. After 5 days distraction was done 1mm per a day for 7 days. A pulsed electromagnetic field (38 Gauss, 60 Hz) was applied for 8 hours per day and it continued for 5 days immediately after distraction in the experimental group. Both groups were sacrificed after 2 weeks. Histological specimens with H&E and Masson Trichrome staining were made and histomorphometrically analysed with image analyser. Results: The device for distraction osteogenesis was displaced in one animal for each group, therefore, only four animals in both groups were evaluated. In both groups, a new bone formation was observed in the distracted area after 2 weeks. The bone formation was enhanced in the experimental groups ($31.76{\pm}8.68%$) compared with control group ($9.94{\pm}3.23%$), its difference was statistically significant (p<0.001). Conclusion: This study suggests that electrical stimulation with electromagnectic field may be effective in the early bone formation after distraction osteogenesis. Further studies with large number of animals are needed before clinical application.
Keywords
Distraction osteogenesis; Electromagnetic field; Bone consolidation;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 McCarthy JG, Schreiber J, Karp N. Thorne Ch et al : Lengtheening the human mandible by gradual distraction. Plast Reconstr Surg 89 : 1, 1992   DOI   ScienceOn
2 Schreuder WH, Jansma J, Bierman MW et al : Distraction osteogenesis versus bilateral sagittal split osteotomy for advancement of the retrognathic mandible: a review of the literature. Int J Oral Maxillofac Surg 36 : 103, 2007   DOI   ScienceOn
3 Saulacic N, Somosa Martin M, de Los Angeles Leon Camacho M et al : Complications in alveolar distraction osteogenesis: a clinical investigation. J Oral Maxillofac Surg. 65 : 267, 2007   DOI   PUBMED   ScienceOn
4 Lente RW : Cases of ununited fracture treated by electricity. NY State J Med 5 : 317, 1850
5 Bassett CAL, Pawluk RJ, Pilla AA : Acceleration of fracture repair by electromagnetic fields: A surgically noninvasive method. Ann N Y Acad Sci 238 : 242, 1974   DOI   PUBMED
6 Ciombor DM, Lester G, Aaron RK et al : Low frequency EMF regulates chondrocyte differentiation and expression of matrix proteins. J Orthop Res 20 : 40, 2002   DOI   ScienceOn
7 KG Hwang, JH Lee, MJ Kim et al.: A study of effect of pulsed electromagnetic fields on osteogenesis in rabbit cranial bone defect. J Kor Oral Maxillofac Surg 28 : 264, 2002
8 Gerling JA, Sinclair PM, Roa RL : The effect of pulsating electromagnetic fields on condylar growth in guinea pigs. Am J Orthop 87 : 211, 1985   DOI   ScienceOn
9 SJ Ryu, CK Yi, BH Choi : Effect of platelet-rich plasma on bone formation in distracted area of canine mandible. J Kor Oral Maxillofac Surg 27 : 498, 2001
10 Hu J, Qi MC, Zou SJ et al : Callus formation enhanced by BMP-7 ex vivo gene therapy during distraction osteogenesis in rats. J Orthop Res 25 : 241, 2007   DOI   ScienceOn
11 Food and Drug Administration : Summary of Safety and Effectiveness: Osteostim HS11 Implantable Bone Growth Stimulator. Silver Spring, Office of Device Evaluation, 1987
12 Fredericks DC, Nepola JV, Baker JT et al : Effects of pulsed electromagnetic fields on bone healing in a rabbit tibial osteotomy model. J Orthop Trauma.14 : 93, 2000   DOI   ScienceOn
13 Lorich DG, Brighton CT, Gupta R et al : Biochemical pathway mediating the response of bone cells to capacitive coupling. Clin Orthop Relat Res. 350 : 246, 1998   PUBMED
14 Ryaby JT : Clinical effects of electromagnetic and electric fields on fracture healing. Clin Orthop 355S : S205, 1998   DOI
15 Bassett CAL, Valdes MG, Hernandez F : Modification of fracture repair with selected pulsing electromagnetic fields. J Bone Joint Surg Am 64A : 888, 1982
16 Luna Gonzalez F, Lopez Arevalo R, Meschian Coretti S et al : Pulsed electromagnetic stimulation of regenerate bone in lengthening procedures. Acta Orthop Belg 71 : 571 2005   PUBMED
17 Block MS, Almerico B, Crawford C et al : Bone response to functioning implants in dog mandibular alveolar ridges augmented with distraction osteogenesis. Int J Oral Maxillofac Implants. 13 : 342, 1998   PUBMED
18 Simonis RB, Parnell EJ, Ray PS et al : Electrical treatment of tibial non-union: a prospective, randomised, double- blind trial. Injury. 34 : 357, 2003   DOI   ScienceOn
19 Kitoh H, Kitakoji T, Tsuchiya H et al : Transplantation of culture expanded bone marrow cells and platelet rich plasma in distraction osteogenesis of the long bones. Bone 40 : 522, 2007   DOI   ScienceOn
20 Friedenberg ZB, Brighton CT : Bioelectric potentials in bone.J Bone Joint Surg Am 48A : 915, 1966
21 Fukada E, Yasuda I : On the piezoelectric effect of bone. J Physiol Soc Jpn 12 : 1158, 1957   DOI
22 Mazzonetto R, Allais M, Maurette PE et al : A retrospec-tive study of the potential complications during alveolar distraction osteogenesis in 55 patients. Int J Oral Maxillofac Surg 36 : 6, 2007   DOI   ScienceOn
23 Luben RA, Cain CD, Chen MC et al : Effects of electromagnetic stimuli on bone and bone cells in vitro: inhibition of responses to parathyroid hormone by low-energy, low frequency fields. Proc Natl Acad Sci 79 : 4180, 1982
24 Blcok MS, Chang A, Crawford C : Mandibular alveolar ridge augmentation in the dog using distraction osteogenesis. J Oral Maxillofac Surg 54 : 309, 1996   DOI   PUBMED   ScienceOn
25 Brighton CT, Shaman P, Heppenstall RB et al : Tibial nonunion treated with direct current, capacitive coupling, or bone graft. Clin Orthop Relat Res 321 : 223, 1995   PUBMED
26 Hagiwara T, Bell W H : Effect of electrical stimulation on mandibular distraction osteogenesis. J Cranio-Maxillofac Surg 28 : 12, 2000   DOI   ScienceOn
27 Borsalino G, Bagnacani M, Bettati E et al : Electrical stimulation of human intertrochanteric osteotomies: Doubleblind study. Clin Orthop 237 : 256, 1988
28 Shao Z, Liu B, Peng Q, Liu W et al : Transplantation of osteoblast-like cells to the distracted callus in the rabbit mandible. Plast Reconstr Surg 119 : 500, 2007   DOI   ScienceOn
29 Zhuang H, Wang W, Seldes RM et al : Electrical stimulation induces the level of TGF-${\beta}1$ mRNA in osteoblastic cells by a mechanism involving calcium/calmodulin pathway. Biochem Biophys Res Comm 237 : 225, 1997   DOI   ScienceOn
30 Tabrah FL, Ross P, Hoffmeier M et al : Clinical report on long-term bone density after short-term EMF application. Bioelectromagnetics 19 : 75, 1998   DOI   ScienceOn
31 Spadoro JA : Bioelectrical properties of bone and response of bone to electrical stimuli. In Bone. Vol 3, CRC Press, Boston, 1991, p. 109
32 Yasuda I : On the piezoelectric property of bone. J Jpn Orthop Surg Soc 28 : 267, 1954
33 Hinsenkamp MG : Treatment of non-unions by electromagnetic stimulation. Acta Orthop Scand Suppl 196 : 63, 1982   PUBMED
34 Spadaro JA, Becker RO : Function of implanted cathodes in electrodeinduced bone growth, Med Biol Eng Comput 17 : 769, 1979   DOI   ScienceOn
35 Fredericks C F, Piehl D, Baker J T et al : Effects of pulsed electromagnetic field stimulating on distraction osteogenesis in the rabbit tibial leg lengthening model. J Pediat Ortho 23 : 478, 2003   DOI   ScienceOn
36 Saltzman C, Lightfoot A, Amendola A : PEMF as treatment for delayed healing of foot and ankle arthrodesis. Foot Ankle Int 25 : 771, 2004   DOI   PUBMED
37 Fitzsimmons RJ, Strong DD, Mohan S et al : Low-amplitude, low frequency electric field-stimulated bone cell proliferation may in part be mediated by increased IGF-II release. J Cell Physiol 150 : 84, 1992   DOI   PUBMED
38 Mayr E, Laule A, Suger G et al : Radiographic results of callus distraction aided by pulsed low-intensity ultrasound. J Orthopaedic Trauma 15 : 407, 2001   DOI   ScienceOn
39 Yen-Patton GP, Patton WF, Beer DM et al : Endothelial cell response to pulsed electromagnetic fields: stimulation of growth rate and angiogenesis in vitro. J Cell Physiol 134 : 37, 1988   DOI   PUBMED
40 SW Kim, KG Hwang, BS Lim et al.: The effect of pulsed magnetic fields on ${\beta}$ -TCP graft in rabbit cranial bone defect. J Kor Oral Maxillofac Surg 32 : 360, 2006   과학기술학회마을
41 Benazzo F, Mosconi M, Beccarisi G et al : Use of capacitive coupled electric fields in stress fractures in athletes. Clin Orthop Relat Res 310 : 145, 1995   PUBMED
42 Taylor KF, Inoue N, Rafiee B et al : Effect of pulsed electromagnetic fields on maturation of regenerate bone in a rabbit limb lengthening model. J Orthop Res 24 : 2, 2006   DOI   ScienceOn
43 Chin M, Toth BA : Distraction osteogenesis in maxillofacial surgery using internal devices: Review of five cases. J Oral Maxillofac Surg 54 : 45, 1996   DOI   PUBMED   ScienceOn
44 Hartshorne E : On the causes and treatment of pseudarthrosis and especially that form of it sometimes called supernumerary joint. Am J Med 1 : 121, 1841
45 Bassett CAL, Pawluk RJ, Pilla AA : Augmentation of bone repair by inductively coupled electromagnetic fields. Science 184 : 575, 1974   DOI   PUBMED   ScienceOn
46 Bodamyali T, Bhatt B, Hughes FJ et al : Pulsed electromagnetic fields simultaneously induce osteogenesis and upregulate transcription of bone morphogenetic proteins 2 and 4 in rat osteoblasts in vitro. Biochem Biophys Res Commun 250 : 458, 1998   DOI   ScienceOn
47 Satoh K, Mitsukawa N, Tosa Y et al : Simultaneous hybrid of maxillary Le Fort I halo distraction and mandibular set-back for patients with severe cleft jaw deformity. J Craniofac Surg. 17 : 962, 2006   DOI   ScienceOn
48 Nout E, Wolvius EB, van Adrichem LN et al : Complications in maxillary distraction using the RED II device: a retrospective analysis of 21 patients. Int J Oral Maxillofac Surg 35 : 897, 2006   DOI   ScienceOn
49 Hodges SD, Eck JC, Humphreys SC : Use of electrical bone stimulation in spinal fusion. J Am Acad Orthop Surg 11 : 81, 2003   DOI   PUBMED
50 Farndale RW, Murray JC : Pulsed electromagnetic fields promote collagen production in bone marrow fibroblasts via athermal mechanisms. Calcif Tissue Int 37 : 178, 1985   DOI   ScienceOn
51 Ilizarov GA : The tension-stress effect on the genesis and growth of tissue : Part I. the influence of stability of fixation and soft-tissue preservation. Clin Orthop 238 : 249, 1989
52 El-Hakim IE, Azim AMA, El-Hassan MFA et al : Preliminary investigation into the effects of electrical stimulation on mandibular distraction osteogenesis in goats. Int. J Oral Maxillofac Surg 33 : 42, 2004   DOI   ScienceOn
53 SH Oh, SK Min, KS Lee, MJ Kang, EC Kim : Early bone formation capacity of PRP on a distraction osteogenesis in rabbit. J Kor Maxillofac Plas Recontr Surg 26 : 521, 2004
54 Rubin CT, McLeod KJ, Lanyon LE : Prevention of osteoporosis by pulsed electromagnetic fields. J Bone Joint Surg [Am] 71 : 411, 1989   DOI   PUBMED
55 Schreuder WH, Jansma J, Bierman MW et al : Distraction osteogenesis versus bilateral sagittal split osteotomy for advancement of the retrognathic mandible: a review of the literature. Int J Oral Maxillofac Surg. 36 : 103, 2007   DOI   ScienceOn
56 Wang L, Zhou S, Liu B et al : Locally applied nerve growth factor enhances bone consolidation in a rabbit model of mandibular distraction osteogenesis. J Orthop Res 24 : 2238, 2006   DOI   ScienceOn
57 Brighton CT, Wang W, Seldes R et al : Signal transduction in electrically stimulated bone cells. J Bone Joint Surg Am 83-A : 1514, 2001
58 Friedenberg ZB, Harlow MC, Brighton CT : Healing of medial malleolus by means of direct current: A case report. J Trauma 11 : 883, 1971   DOI   PUBMED   ScienceOn
59 Kushner A : Evaluation of Wolff's law of bone formation. J Bone J Surg 22 : 589, 1940
60 Cruess RL, Kan K, Bassett CA : The effect of pulsing electromagnetic fields on bone metabolism in experimental disuse osteoporosis. Clin Orthop 173 : 245, 1983
61 Ilizarov GA : The tension-stress effect on the genesis and growth of tissue: Part II. the influence of rate and frequency of distraction. Clin Orthop 239 : 263, 1989
62 Bodamyali T, Bhatt B, Hughes JF et al. Pulsed electromagnetic fields simultaneously induce osteogenesis and upregulate transcription of bone morphogenic proteins 2 and 4 in rat osteoblasts in vitro. Biochem Biophys Res Comm 250 : 458, 1998   DOI   ScienceOn
63 Bodamyal T, Kanczler JM, Simon B et al : Effect of faradic products on direct current-stimulated calvarial organ culture calcium levels, Biochem Biophys Res Commun. 264 : 657, 1999   DOI   ScienceOn
64 Hwang SJ, Jung JG, Jung JU et al : Vertical alveolar bone distraction at molar region using lag screw principle. J Oral Maxillofac Surg 62 : 787, 2004   DOI   ScienceOn
65 Miloro M, Miller JJ, Stoner JA : Low-level laser effect on mandibular distraction osteogenesis. J Oral Maxillofac Surg 65 : 168, 2007   DOI   ScienceOn
66 Bax BE, Alam AS, Banerji B et al : Stimulation of osteoclastic bone resorption by hydrogen peroxide, Biochem Biophys Res Commun 183 : 1153, 1992   DOI   ScienceOn
67 Marino AA, Becker RO : Origin of the piezoelectric effect in bone. Calcif Tissue Res 8 : 177, 1971   DOI   ScienceOn
68 Hastings GW, Mahmud FA : Electrical effects in bone. J Biomed Eng 10 : 515, 1988   DOI   ScienceOn