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http://dx.doi.org/10.7783/KJMCS.2019.27.3.218

Enhancement of Respiratory Protective and Therapeutic Effect of Salvia plebeia R. Br. Extracts in Combination with Korean Red Ginseng  

Shin, Han Jae (KT&G Research Institute)
Gwak, Hyo Min (KT&G Research Institute)
Lee, Moon Yong (KT&G Research Institute)
Kyung, Jong Su (KGC Research Institute)
Jang, Kyoung Hwa (KGC Research Institute)
Han, Chang Kyun (KGC Research Institute)
Yang, Won Kyung (Institute of Traditional Medicine and Bioscience, Daejeon University)
Kim, Seung Hyung (Institute of Traditional Medicine and Bioscience, Daejeon University)
Publication Information
Korean Journal of Medicinal Crop Science / v.27, no.3, 2019 , pp. 218-231 More about this Journal
Abstract
Background: We recently reported that Salvia plebeia R. Br. extracts suppress leukotriene production and effectively inhibit the airway inflammatory response by modulating inflammatory chemokine and cytokine expression. Here, we investigated the synergistic airway anti-inflammation effect of Salvia plebeia and Panax ginseng (Korean red ginseng, KRG) that has been used to treat various immune diseases such as asthma. Methods and Results: To evaluate the synergistic airway anti-inflammatory effect of Salvia plebeia and KRG, we measured the inhibitory effect of monotheraphy with either or co-theraphy with both on leukotriene and reactive oxygen species (ROS) production. Using coal a combustion, fly ash, and diesel exhaust particle (CFD)-induced respiratory disease mouse model, we found that co-theraphy synergistically suppressed airway inflammatory signs such as alveolar wall thickness and collagen fibers deposition, and decreased the number of total cell, $CD11b^+Gr-1^+$ cells, and inflammatory cytokines (IL17A, TNF, MIP-2 and CXCL-1) in bronchoalveolar lavage (BAL) fluid. Conclusions: We confirmed respiratory protection as a therapeutic effect of the Salbia plebeia-KRG 3 : 1 complex (KGC-03-PS) via anti-tracheal muscle contraction and expectorant animal studies using a CFD-induced respiratory disease mouse model.
Keywords
Salvia plebeia R. Br.; Korean Red Ginseng (KRG); CFD-Induced Respiratory Disease Model; Airway Inflammation;
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1 Kim DH, Kwak KH, Lee KJ, Kim SJ, Shin YC, Chun BG and Shin KH. (2004). Effect of Korea red ginseng total saponin on repeated unpredictable stress-induced changes of proliferation of neural progenitor cells and BDNF mRNA expression in adult rat hippocampus. Journal of Ginseng Research. 28:94-103.   DOI
2 Kim JH, Lee TJ, Im JA and Lee DC. (2014). Effect of Korean red ginseng on artificial sand dust(ASD) induced allergic lung inflammation. Biomedical Science Letters. 20:173-179.   DOI
3 Kolaczkowska E and Kubes P. (2013). Neutrophil recruitment and function in health and inflammation. Nature Reviews Immunology. 13:159-175.   DOI
4 Lee WC, Jung HA, Choi JS, Kim YS and Lee SM. (2011). Protective effects of luteolin against apoptotic liver damage induced by D-galactosamine/lipopolysaccharide in mice. Journal of Natural Productions. 74:1916-1921.   DOI
5 Liang Z, Nie H, Xu Y, Peng J, Zeng Y, Wei Y, Wen X, Qiu J, Zhong W, Deng X and He J. (2016). Therapeutic effects of rosmarinic acid on airway responses in a murine model of asthma. International Immunopharmacology. 41:90-97.   DOI
6 Lim HB and Kim SH. (2009). The effect of crude saponins of Korean red ginseng against airway inflammation and airway hyperresponsiveness induced by exhaust particles in mice. Korean Journal of Medicinal Crop Science. 17:90-96.
7 Lin BQ, Li PB, Wang YG, Peng W, Wu Z, Su WW and Ji H. (2008). The expectorant activity of naringenin. Pulmonary Pharmacology & Therapeutics. 21:259-263.   DOI
8 Mahady, Gail B, Fong, Harry HS and Farnsworth NR. (2001). Botanical Dietary Supplements. CRC Press. Boca Raton. FL, USA. p.207-215.
9 Nam KY. (2005). The comparative understanding between red ginseng and white ginseng processed ginseng(Panax ginseng C.A. Meyer). Journal of Ginseng Research. 29:1-18.   DOI
10 Nials AT and Uddin S. (2008). Mouse models of allergic asthma: Acute and chronic allergen challenge. Disease Models and Mechanisms. 1:213-220.   DOI
11 Wichmann HE. (2007). Diesel exhaust particles. Inhalation Toxicology. 19:241-244.   DOI
12 Shin HJ, Gwak HM, Jang M, Park SH, Min HJ, Lee JM, Lee MY, Kim JH, Kim SW, Han CK and Kim SH. (2016). Aniinflammatory activity of three kinds of Salvia and its active compounds. Korea Journal of Medicinal Crop Science. 24:401-407.   DOI
13 Song HW, Ji KY, Kim BK, Yang WK, Han CK, Shin HJ, Park YC, Hwang JS, Kang HS and Kim SH. (2017). Respiratory protective effect of Salvia plebeia R. Br. extracts against ambient particulate matter-induced airway inflammation. Korea Journal of Medicinal Crop Science. 25:269-281.   DOI
14 Talib WH, Zarga MH and Mahasneh AM. (2012). Antiproliferative, antimicrobial and apoptosis inducing effects of compounds isolated from Inula viscosa. Molecules. 17:3291-3303.   DOI
15 Yin Y, Gong FY, Wu XX, Sun Y, Li YH, Chen T and Xu Q. (2008). Anti-inflammatory and immunosuppressive effect of flavones isolated from Artemisia vestita. Journal of Ethnopharmacology. 120:1-6.   DOI
16 Yoshitaka I. (2007). Research on the quality distribution of JIS type-II fly ash in Japan. World of Coal Ash. www.flyash.info/2007/67ishikawa.pdf (cited by 2019 May 7).
17 Bohadana AB, Massin N, Wild P, Toamain JP, Engel S and Goutet P. (2000). Symptoms, airway responsiveness, and exposure to dust in beech and oak wood workers. Occupational and Environmental Medicine. 57:268-273.   DOI
18 Akiyama K. (2006). Gas chromatographic analysis and aerosol mass spectrometer measurement of diesel exhaust particles composition. Talanta. 70:178-181.   DOI
19 Bae KC and Kim SH. (1998). Antioxidant effects of Korea ginseng radix, Korean red ginseng radix and total saponin. Korean Journal Oriental Medical Pathology. 12:72-81.
20 Barnes PJ. (1994). Cytokines as mediators of chronic asthma. American Journal of Respiratory and Critical Care Medicine. 150:42-49.   DOI
21 Brandt EB, Kovacic MB, Lee GB, Gibson AM, Acciani TH, Le Cras TD, Ryan PH, Budelsky AL, Khurana and Hershey GK. (2013). Diesel exhaust particle induction of IL-17A contributes to severe asthma. Journal of Allergy and Clinical Immunology. 132:1194-1204.   DOI
22 Chen T, Xiao L, Zhu L, Ma S, Yan T and Ji H. (2015). Antiasthmatic effects of ginsenoside Rb1 in a mouse model of allergic asthma through relegating Th1/Th2. Inflammation. 38:1814-1822.   DOI
23 Choi SI, Cho IH, Han SH, Jeon YJ, Choi JG, Kim JS and Lee JH. (2016). Antiobesity effects of Salvia plebeia R. Br. extract in high-fat diet-induced obese mice. Journal of Medicinal Food. 19:1048-1056.   DOI
24 Cho BO, Yin HH, Fang CZ, Ha HO, Kim SJ, Jeong SI and Jang SI. (2015). Synergistic anti-inflammatory effect of rosmarinic acid and luteolin in lipopolysaccharide-stimulated RAW264.7 macrophage cells. Korean Journal of Food Science and Biotechnology. 47:119-125.   DOI
25 Cho YS, Lee JT, Jung CH, Chun YS and Kim YS. (2008). Relation between particulate matter measured by optical particle counter and mortality in Seoul, Korea, during 2001. Journal of Environmental Health. 71:37-43.
26 Choi JK, Oh HM, Lee SY, Kwon TK, Shin TY, Rho MC and Kim SH. (2014). Salvia plebeia suppresses atopic dermatitislike skin lesions. The American Journal of Chinese Medicine. 42:967-985.   DOI
27 Costa RS, Carneiro TC, Cerqueira-Lima AT, Queiroz NV, Alcantara-Neves NM, Pontes-de-Carvalho LC, Velozo Eda S, Oliveira EJ and Figueiredo CA. (2012). Ocimum gratissimum Linn. and rosmarinic acid, attenuate eosinophilic airway inflammation in an experimental model of respiratory allergy to Blomia tropicalis. International Immunopharmacology. 13:126-134.   DOI
28 Ghio AJ, Smith CB and Madden MC. (2012). Diesel exhaust particles and airway inflammation. Current Opinion in Pulmonary Medicine. 18:144-150.   DOI
29 Gu L and Weng X. (2001). Antioxidant activity and components of Salvia plebeia R. Br. Chinese Herb. Food Chemistry. 73:299-305.   DOI
30 Inoue KI, Koike E, Yanagisawa R and Takano H. (2008). Effects of pulmonary exposure to diesel exhaust particles on extrathoracic CD4 polarization in asthmatic mice. Immunopharmacology and Immunotoxicology. 31:1-6.   DOI
31 Jones TR, Labelle M, Belley M, Champion E, Charette L, Evans J, Ford-Hutchinson AW, Gauthier JY, Lord A, Masson P, McAuliffe M, McFarlane CS, Metters KM, Pickett C, Piechuta H, Rochette C, Rodger IW, Sawyer N, Yoyng RN, Zamboni R and Abraham WM. (1995). Pharmacology of montelukast sodium(Singulair), a potent and selective leukotriene $D_4$ receptor antagonist. Canadian Journal of Physiology and Pharmacology. 73:191-201.   DOI
32 Jang HH, Cho SY, Kim MJ, Kim JB, Lee SH, Lee MY and Lee YM. (2016). Anti-inflammatory effects of Salvia plebeia R. Br extract in vitro and in ovalbumin-induced mouse model. Biological Research. 49:41. https://doi.org/10.1186/s40659-016-0102-7 (cited by 2019 May 5).   DOI
33 Jang TY, Jung AY, Kyung TS, Kim DY, Hwang JH and Kim YH. (2017). Anti-allergic effect of luteolin in mice with allergic asthma and rhinitis. Central-European Journal of Immunology. 42:24-29.   DOI
34 Jeon BH, Kim HS and Chang SJ. (1999). Effect of saponin and non-saponin of on Panax ginseng on the blood pressure in the renovascular hypertensive rats. Journal of Ginseng Research. 23:81-87.
35 Jung KY, Kim DS, Oh SR, Lee IS, Lee JJ, Park JD, Kim SI and Lee HK. (1998). Platelet activating factor antagonist activity of ginsenosides. Biological and Pharmaceutical Bulletin. 21:79-80.   DOI
36 Keum YS, Park KK, Lee JM, Chun KS, Park JH, Lee SK, Kwon HJ and Surh YJ. (2000). Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng. Cancer Letters. 150:41-48.   DOI