Water Extract of Taraxaci Radix Improves Rheumatoid Arthritis Induced by Type-II Collagen in Animal Models
![]() |
Nho, Jong Hyun
(National Development Institute of Korean Medicine)
Lee, Hyun Joo (National Development Institute of Korean Medicine) Jang, Ji Hun (National Development Institute of Korean Medicine) Yang, Beo Dul (National Development Institute of Korean Medicine) Kim, A Hyeon (National Development Institute of Korean Medicine) Woo, Kyeong Wan (National Development Institute of Korean Medicine) Hwang, Tae Yeon (National Development Institute of Korean Medicine) Seo, Jae Wan (National Development Institute of Korean Medicine) Cho, Hyun Woo (National Development Institute of Korean Medicine) Jung, Ho Kyung (National Development Institute of Korean Medicine) |
1 | Bradley JR. (2008). TNF-mediated inflammatory disease. Journal of Pathology. 214:149-160. DOI |
2 | Burmester GR, Dimitriu-Bona A, Waters SJ and Winchester RJ. (1983). Identification of three major synovial lining cell populations by monoclonal antibodies directed to Ia antigens and antigens associated with monocytes/macrophages and fibroblasts. Scandinavian Journal of Immunology. 17:69-82. DOI |
3 | Cheon YH, Kim HO, Suh YS, Hur JH, Jo WY, Lim HS, Hah YS, Sung MJ, Kwon DY and Lee SI. (2015). Inhibitory effects for rheumatoid arthritis of dietary supplementation with resveratrol in collagen-induced arthritis. Journal of Rheumatic Diseases. 22:93-101. DOI |
4 | Choi KH, Nam HH and Choo BK. (2013). Effect of five Korean native Taraxacum on antioxidant activity and nitric oxide production inhibitory activity. Korean Journal of Medicinal Crop Science. 21:191-196. DOI |
5 | De S, Manna A, Kundu S, de Sarkar S, Chatterjee U, Sen T, Chattopadhyay S and Chatterjee M. (2017). Allylpyrocatechol attenuates collagen-induced arthritis via attenuation of oxidative stress secondary to modulation of the MAPK, JAK/STAT, and Nrf2/HO-1 pathways. Journal of Pharmacology and Experimental Therapeutics. 360:249-259. DOI |
6 | Endale M, Lee WM, Kwak YS, Kim NM, Kim BK, Kim SH, Cho JY, Kim S, Park SC, Yun BS, Ko DH and Rhee MH. (2013). Torilin ameliorates type II collagen-induced arthritis in mouse model of rheumatoid arthritis. International Immunophamacology. 16:232-242. DOI |
7 | Kim YO, Lee SW and Lee SE. (2009). Effects of Achyrantes japonica on carrageenan-induced arthritis rat model. Korean Journal of Medicinal Crop Science. 17:470-474. |
8 | Kwon OG and An HD. (2013). Articular cartilage protective effects of Kangwhaldoche-tang(Qiānghuódǎozhì-tāng) aqueous extracts on the adjuvant-induced rat rheumatoid arthritis. Journal of Oriental Rehabillitation Medicine. 23:49-61. |
9 | Lee DM and Weinblatt ME. (2001). Rhematoid arthritis. Lancet. 358:903-911. DOI |
10 | Lee HH and Lee SY. (2008). Cytotoxic and antioxidant effects of Taraxacum coreanum Nakai. and T. officinale WEB. extracts. Korean Journal of Medicinal Crop Science. 16:79-85. |
11 | Nishikawa M, Myoui A, Tomita T, Takahi K, Nampei A and Yoshikawa H. (2003). Prevention of the onset and progression of collagen-induced arthritis in rats by the potent p38 mitogenactivated protein kinase inhibitor FR167653. Arthritis and Rheumatology. 48:2670-2681. DOI |
12 | Patel SB, Santani D, Patel V and Shah M. (2015). Anti-diabetic effects of ethanol extract of Bryonia laciniosa seeds and its saponins rich fraction in neonatally streptozotocin-induced diabetic rats. Pharmacognosy Research. 7:92-99. DOI |
13 | Patel SB, Santani D, Shah MB and Patel VS. (2012). Antihyperglycemic and anti-hyperlipidemic effects of Bryonia laciniosa seed extract and its saponin fraction in streptozotocininduced diabetes in rats. Journal of Young Pharmacists. 43:171-176. |
14 |
Piao T, Ma Z, Li X and Liu J. (2015). Taraxasterol inhibits IL-1 |
15 | Ryu JH, Seo KS, Kuk YI, Moon JH, Ma KH, Choi SK, Rha ES, Lee SC and Bae CH. (2012). Effects of LED(light-emitting diode) treatment on antioxidant activities and functional components in Taraxacum officinale. Korean Journal of Medicinal Crop Science. 20:165-170. DOI |
16 |
Saxne T, Palladino Ma, Heinegard D, Talal N and Wollheim FA. (1988). Detection of tumor necrosis factor |
17 | Sun J, Jia Y, Li R, Guo J, Sun X, Liu Y, Li Y, Yao H, Liu X, Zhao J and Li Z. (2011). Altered influenza virus haemagglutinin (HA)-derived peptide is potent therapy for CIA by inducing Th1 to Th2 shift. Cellular and Molecular Immunology. 8:348-358. DOI |
18 | Seo HH and Jeong JM. (2014). Inhibitory effects of complex of Mulberry extract on degenerative arthritis. Korean Journal of Medicinal Crop Science. 22:262-269. DOI |
19 | Shingu M, Nagai Y, Isayama T, Naono T, Nobunaga M and Nagai Y. (1993). The effects of cytokines on metalloproteinase inhibitors(TIMP) and collagenase production by human chondrocytes and TIMP production by synovial cells and endothelial cells. Clinical and Experimental Immunology. 94:145-149. DOI |
20 | Song HP, Li X, Yu R, Zeng G, Yuan ZY, Wang W, Huang HY and Cai X. (2015). Phenotypic characterization of type II collagen-induced arthritis in wistar rats. Experimental and Therapeutic Medicine. 10:1483-1488. DOI |
21 | Sun Y, Zhao DL, Liu ZX, Sun XH and Li Y. (2017). Beneficial effect of 20-hydroxyecdysone exerted by modulating antioxidants and inflammatory cytokine levels in collagen-induced arthritis: A model for rheumatoid arthritis. Molecular Medicine Reports. 16:6162-6169. DOI |
22 | Tanaka T, Narazaki M and Kishimoto T. (2014). IL-6 in inflammation, immunity, and disease. Cold Spring Harbor Perspectives in Biology. https://cshperspectives.cshlp.org/content/early/2014/09/04/cshperspect.a016295.short.6:a016295 (cited by 2019 Jan 8). |
23 | Wang S, Wang Y, Liu X, Guan L, Yu L and Zhang H. (2016). Anti-inflammatory and anti-arthritic effects of taraxasterol on adjuvant-induced arthritis in rats. Journal of Ethnopharmacology. 187:42-48. DOI |
24 | Kang MJ, Seo YH, Kim JB, Shin SR and Kim KS. (2000). The chemical composition of Taraxacum officinale consumed in Korea. Korean Journal of Food and Cookery Science. 16:182-187. |
25 | Watcho P, Zelefack F, Nguelefack TB, Ngouela S, Telefo PB, Kamtchouing P, Tsamo E and Kamanyi A. (2006). Effects of the aqueous and hexane extracts of Mondia whitei on the sexual behaviour and some fertility parameters of sexually inexperienced male rats. African Journal of Traditional, Complement and Alternative Medicines. 4:37-46. |
26 | Whittle SL and Hughes RA. (2004). Folate supplementation and methotrexate treatment in rheumatoid arthritis: A review. Rheumatology. 43:267-271. DOI |
27 |
Fujita H, Yamagami T and Ohshima K. (2001). Fermented soybean-derived water-soluble Touchi extract inhibits |
28 | Furst DE and Emery P. (2014). Rheumatoid arthritis pathophysiology: Update on emerging cytokine and cytokineassociated cell targets. Rheumatology. 53:1560-1569. DOI |
29 | Gordon S and Taylor PR. (2005). Monocyte and macrophage heterogeneity. Nature Reviews Immunology. 5:953-964. DOI |
30 | Jung YO, Hong SJ and Kim HY. (2003). Role of immune response to type II collagen in the pathogenesis of rheumatoid arthritis. Immune Network. 3:1-7. DOI |
31 | Kang MJ, Shin SR and Kim KS. (2002). Antioxidative and free radical scavenging activity of water extract from dandelion (Taraxacum officinale). Korean Journal of Food Preservation. 9:253-259. |
32 | Kim GS, Kim HJ, Lee DY, Choi SM, Lee SE, Noh HJ, Choi JG and Choi SI. (2013a). Effects of supercritical fluid extract, shikonin and acetylshikonin from Lithospermum erythrorhizon on chondrocytes and MIA-induced osteoarthritis in rats. Korean Journal of Medicinal Crop Science. 21:466-473. DOI |
33 | Kim WJ, Moon BC, Ji Y, Lee YM and Kim HK. (2013b). Genetic diversity of the original plant for Taraxaci Herba, Taraxacum spp. by the analysis of AFLP. Korean Journal of Medicinal Crop Science. 21:247-254. DOI |
34 | Feldmann M, Brennan FM and Mainil RN. (1996). Role of cytokines in rheumatoid arthritis. Annual Review of Immunology. 14:397-440. DOI |
![]() |