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http://dx.doi.org/10.7783/KJMCS.2017.25.6.353

Ameliorating Effects of Cinnamomum loureiroi and Rosa laevigata Extracts Mixture against Trimethyltin-induced Learning and Memory Impairment Model  

Choi, Soo Jung (Functional Food Research Center, Korea University)
Kim, Cho Rong (Department of Food and Biotechnology, Korea University)
Park, Chan Kyu (Department of Food and Biotechnology, Korea University)
Gim, Min Chul (Department of Food and Biotechnology, Korea University)
Choi, Jong Hun (Natural Way Co., Ltd.)
Shin, Dong Hoon (Department of Food and Biotechnology, Korea University)
Publication Information
Korean Journal of Medicinal Crop Science / v.25, no.6, 2017 , pp. 353-360 More about this Journal
Abstract
Background: A critical features of Alzheimer's disease (AD) is cognitive dysfunction, which partly arises from decreased in acetylcholine levels. AD afftected brains are characterized by extensive oxidative stress, which is thought to be primarily induced by the amyloid beta ($A{\beta}$) peptide. In a previous study, Cinnamomum loureiroi tincture inhibited acetylcholinesterase (AchE) activity. That study identified AChE inhibitor in the C. loureiroi extract. Furthermore, the C. loureiroi extract enhanced memory in a trimethyltin (TMT)-induced model of cognitive dysfunction, as assessed via two behavioral tests. Rosa laevigata extract protected against oxidative stress-induced cytotoxicity. Administrating R. laevigata extracts to mice significantly reversed $A{\beta}$-induced learning and memory impairment, as shown in behavioral tests. Methods and Results: We conducted behavioral to examine the synergistic effects of C. loureiroi and R. laevigata extracts in inhibiting AChE and counteracting TMT-induced learning and memory losses. We also performed biochemical assays. The biochemical results showed a relationship between increased oxidative stress and cholinergic neurons damage in TMT-treated mice. Conclusions: A diet containing C. loureiroi and R. laevigata extracts ameliorated learning and memory impairments in the Y-maze and passive avoidance tests, and exerted synergistic inhibitory effect against AChE and lipid peroxidation.
Keywords
Cinnamomum loureiroi; Rosa laevigata; Alzheimer's Disease; Learning; Memory;
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Times Cited By KSCI : 2  (Citation Analysis)
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