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http://dx.doi.org/10.7783/KJMCS.2017.25.5.305

Antioxidant Activity and NO Inhibitory Effect of Bioconverted Medicinal Material Using Germinated Green Rice and Hericium erinaceus Mycelium  

Lee, Young Min (Department of Applied Biochemistry, Konkuk University)
Kim, In Sook (Department of Applied Biochemistry, Konkuk University)
Ghosh, Mithun (Department of Applied Biochemistry, Konkuk University)
Hong, Seong Min (Department of Applied Biochemistry, Konkuk University)
Lee, Taek Hwan (AG-Health Research Center)
Lee, Dong Hee (Gyeongbuk Institute for Bio Industry)
Lim, Beong Ou (Department of Applied Biochemistry, Konkuk University)
Publication Information
Korean Journal of Medicinal Crop Science / v.25, no.5, 2017 , pp. 305-314 More about this Journal
Abstract
Background: Hericium erinaceus is considered a functional food and potential medicinal source. The present study was conducted to examine the potential antioxidant and anti-inflammatory activities of carried out with water and ethanol extracts of Hericium erinaceus grown on germinated green rice (HEGR-W and HEGR-E, respectively) and the water and ethanol extracts of germinated green rice (GR-W and GR-E, respectively) as potential medicinal resources or antioxidant and anti-inflammatory agents. Methods and Results: The total phenolic and flavonoid contents, DPPH, and ABTS activity, reducing power, DNA protective activity, cell viability, and NO production were investigated. The total phenolic and flavonoid contents were highest in HEGR-E ($66.53{\pm}2.40 mg{\cdot}GAE/100g$ and $82.12{\pm}7.10mg{\cdot}CE/100g$ respectively). HEGR-E exhibited high DPPH ($44.70{\pm}1.28%$) and, ABTS ($44.70{\pm}1.28%$) activity and reducing power (0.219). HEGR and GR extracts showed protective activity against DNA damage. The cytotoxicity of HEGR and GR in RAW264.7 cells and LPS-induced RAW264.7 cells was low. HEGR-E and GR-W exhibited anti-inflammatory effects through a 28% inhibition of NO production in LPS-induced RAW264.7 cells. Conclusions: These results suggested that the extracts of Hericium erinaceus grown on germinated green rice could be a potential medicinal material with natural antioxidant and NO inhibitory properties.
Keywords
Hericium erinaceus; Antioxidant; DNA Protection; DPPH; Green Rice; NO;
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Times Cited By KSCI : 9  (Citation Analysis)
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