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http://dx.doi.org/10.7783/KJMCS.2016.24.5.341

Effect of Valeriana fauriei Extract on the Neurodevelopmental Proteins Expression and Behavioral Patterns in Maternal Immune Activation Animal Model  

Won, Hansol (Department of Clinical Pharmacology, College of Medicine, Soonchunhyang University)
Kim, Young Ock (Development of Ginseng and Medical Plants Research Institute, NIHHS, RDA)
Lee, Hwayoung (Department of Clinical Pharmacology, College of Medicine, Soonchunhyang University)
Im, Jiyun (Department of Clinical Pharmacology, College of Medicine, Soonchunhyang University)
Lee, Sanghyun (Department of Integrative Plant Science, Chungang University)
Cho, Ik Hyun (Department of Convergence Medical Science, Brain Korea 21 Plus Program, and Institute of Korean Medicine, College of Oriental Medicine, Kyunghee University)
Lee, Sang Won (Development of Ginseng and Medical Plants Research Institute, NIHHS, RDA)
Park, Chun Geun (Development of Ginseng and Medical Plants Research Institute, NIHHS, RDA)
Kim, Hyung Ki (Department of Clinical Pharmacology, College of Medicine, Soonchunhyang University)
Kwon, Jun Tack (Department of Clinical Pharmacology, College of Medicine, Soonchunhyang University)
Kim, Hak Jae (Department of Clinical Pharmacology, College of Medicine, Soonchunhyang University)
Publication Information
Korean Journal of Medicinal Crop Science / v.24, no.5, 2016 , pp. 341-350 More about this Journal
Abstract
Background: Prenatal exposure to infectious and/or inflammatory insults can increase the risk of developing neuropsychiatric disorder such as bipolar disorder, autism, and schizophrenia later in life. We investigated whether Valeriana fauriei (VF) treatment alleviates prepulse inhibition (PPI) deficits and social interaction impairment induced by maternal immune activation (MIA). Methods and Results: Pregnant mice were exposed to polyriboinosinic-polyribocytidilic acid (5 mg/kg, viral infection mimic) on gestational day 9. The adolescent offspring received daily oral treatment with VF (100 mg/kg) and injections of clozapine (5 mg/kg) for 30 days starting on the postnatal day 35. The effects of VF extract treatment on behavioral activity impairment and protein expression were investigated using the PPI analysis, forced swim test (FST), open field test (OFT), social interaction test (SIT), and immunohistochemistry. The MIA-induced offspring showed deficits in the PPI, FST, OFT, and SIT compared to their non MIA-induced counterparts. Treatment with the VF extract significantly recovered the sensorimotor gating deficits and partially recovered the aggressive behavior observed in the SIT. The VF extract also reversed the downregulation of protein expression induced by MIA in the medial prefrontal cortex. Conclusions: Our results provide initial evidence of the fact that the VF extract could reverse MIA-induced behavioral impairment and prevent neurodevelopmental disorders such as schizophrenia.
Keywords
Valeriana fauriei Briq.; Maternal Immune Activation; Polyriboinosinic-Polyribocytidilic Acid; Schizophrenia;
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Times Cited By KSCI : 3  (Citation Analysis)
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