Browse > Article
http://dx.doi.org/10.7783/KJMCS.2016.24.1.38

Whitening and Anti-Wrinkle Effects of Tremella Fuciformis Extracts  

Lee, Kwang Ho (Central Research Institue of Hawon Pharmaceutical)
Park, Hyun Soo (Central Research Institue of Hawon Pharmaceutical)
Yoon, Il Joo (Central Research Institue of Hawon Pharmaceutical)
Shin, Young Bong (Central Research Institue of Hawon Pharmaceutical)
Baik, Young Chan (Central Research Institue of Hawon Pharmaceutical)
Kooh, Dae Ho (Central Research Institue of Hawon Pharmaceutical)
Kim, Sung Kew (Central Research Institue of Hawon Pharmaceutical)
Jung, Ho Kyung (Jeollanamdo Development Institute of Korean Traditional Medicine)
Sim, Mi Ok (Jeollanamdo Development Institute of Korean Traditional Medicine)
Cho, Hyun Woo (Jeollanamdo Development Institute of Korean Traditional Medicine)
Jung, Won Seok (Jeollanamdo Development Institute of Korean Traditional Medicine)
Kim, Myoung Seok (Central Research Institue of Hawon Pharmaceutical)
Publication Information
Korean Journal of Medicinal Crop Science / v.24, no.1, 2016 , pp. 38-46 More about this Journal
Abstract
Background : The white jelly mushroom (Tremella fuciformis), one of the most popular edible fungi, has medicinal properties. However, the effects of T. fuciformis in skin whitening or anti-wrinkle efficacy has not been defined to date. The aim of the present study was to investigate the effects of T. fuciformis extracts on whitening and anti-wrinkle efficacy in skin cells. Methods and Results :We prepared T. fuciformis extracts with water. The extracts ($80^{\circ}C$) contained 12.11 mg/g polyphenol and 8.54 mg/g flavonoid concentration. T. fuciformis extracts markedly decreased melanin contents and tyrosinase activity in ${\alpha}$-MSH-stimulated melanocytes (B16F10 cells). In addition, the mRNA expression of melanin formation factors, such as microphthalmia-associated transcription factor (MITF), tyrosinase-related protein-1 (TRP-1) and tyrosinase-related protein-2 (TRP-2) were significantly down-regulated in ${\alpha}$-MSH-stimulated melanocyte. Furthermore, T. fuciformis extracts increased the synthesis of type I procollagen and reduced mRNA expression of matrix metalloproteinase 1 (MMP-1) in the human dermal fibroblast (HDFn cells). These data indicated that T. fuciformis extracts induce repression of cellular melanogenesis and protect against wrinkles caused by UVB-stimulated damage. Conclusions : Thus T. fuciformis extracts could be a cosmetic candidate for skin whitening and anti-wrinkle effects.
Keywords
Tremella fuciformis; Anti-Wrinkle; Collagen; Melanin; Natural Product; Whitening;
Citations & Related Records
Times Cited By KSCI : 11  (Citation Analysis)
연도 인용수 순위
1 Suh SS, Hwang J, Park M, Park HS and Lee TK. (2014). Phenol content, antioxidant and tyrosinase inhibitory activity of mangrove plants in micronesia. Asian Pacific Journal of Tropical Medicine. 7:531-535.   DOI
2 Thody AJ and Graham A. (1998). Does ${\alpha}$-MSH have a role in regulating skin pigmentation in humans? Pigment Cell Research. 11:265-274.   DOI
3 Ukai S, Hirose K, Kiho T, Hara C and Irikura T. (1972). Antitumor activity on sarcoma 180 of the polysaccharides from Tremella fuciformis Berk. Chemical and Pharmaceutical Bulletin. 20:2293-2294.   DOI
4 Urabe K, Aroca P, Tsukamoto K, Mascagna D, Paulumbo A, Prota G and Hearing VJ. (1994). The inherent cytotoxicity of melanin precursors: A revision. Biochimica et Biophysica Acta. 1221:272-278.   DOI
5 Wu M, Hemesath TJ, Takemoto CM, Horstmann MA, Wells AG, Price ER, Fisher DZ and Fisher DE. (2000). c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi. Genes and Development. 14:301-312.
6 Bradford MM. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry. 72:248-254.   DOI
7 Cheung PCK. (1996). The hypocholesterolemic effects of two edible mushrooms: Auricularia auricula(tree-ear) and Tremella fuciformis(white jelly-leaf) in hypocholesterolemic rats. Nutrition Research. 16:1721-1725.   DOI
8 Brenneisen P, Sies H and Scharffetter-Kochanek K. (2002). Ultraviolet-B irradiation and matrix metalloproteinases: From induction via signaling to initial events. Annals of the New York Academy of Sciences. 973:31-43.   DOI
9 Chen FF and Cai DL. (2008). Research advances in primary biological effects of Tremella polysaccharides. Chinese Journal of Integrative Medicine. 6:862-866.   DOI
10 Cheng HH, Hou WC and Lu ML. (2002). Interactions of lipid metabolism and intestinal physiology with Tremella fuciformis Berk edible mushroom in rats fed a high-cholesterol diet with or without nebacitin. Journal of Agricultural and Food Chemistry. 50:7438-7443.   DOI
11 Chun HJ, Choi WH, Baek SH and Woo WH. (2002). Effect of quercetin on melanogenesis in mela-${\alpha}$ melanocyte cells. Korean Journal of Pharmacognosy. 33:245-251.
12 Jun HJ, Lee SY, Kim JH, An BJ and Lee JY. (2013). Anti-wrinkling effects of Juniperus rigida Sied. Korean Journal of Microbiology and Biotechnology. 41:449-455.   DOI
13 Jung HK, Jang JH, Ko JH, Kang BM, Yeo JH, Cho JH, Cho HW, Bean CG, Kim SC and Jung WS. (2014). Whitening and anti-wrinkle effects of Korean native Dendrobium moniliforme methanol extract. Korean Journal of Medicinal Crop Sciences. 22:331-338.   DOI
14 Jung HK, Jang JH, Sim MO, Lee KH, Yeo JH, Kang BM, Cho JH, Bean CG, Kim SC and Jung WS. (2015). Effect of Dendrobium loddigesii Rolfe methanol extract on melanogenesis in ${\alpha}$-MSH stimulated B16F10 cells. Korean Journal of Medicinal Crop Sciences. 23:298-304.   DOI
15 Kim NY and Lee HY. (2015b). Enhancement of anti-wrinkle activities of Abeliophyllum distichum Nakai through low temperature extraction process. Korean Journal of Medicinal Crop Sciences. 23:231-236.   DOI
16 Kim BY, Kim TG, Kang WY, Baek H, Cheon HY and Kim D. (2010). Functional cosmetic effect of porcine placenta. Korean Chemical Engineering Research. 48:327-331.
17 Kim HM, Hur W and Lee SY. (2011). Polysaccharide extraction and comparison of free radical scavenging activities from Tremella fuciformis and Auricularia auricula fruit body. Food Engineering Progress. 15:6-14.
18 Kim NY and Lee HY. (2015a). Effect of antioxidant and skin whitening of ethanol extracts from ultrasonic pretreated Abeliophyllum distichum Nakai. Korean Journal of Medicinal Crop Sciences. 23:155-160.   DOI
19 Kim NY, Park DS and Lee HY. (2015). Effect of anti-skin wrinkle and antioxidant of Agastache rugosa Kentz through fermentation process of the lactic acid. Korean Journal of Medicinal Crop Sciences. 23:37-42.   DOI
20 Ko MS, Lee SJ and Kang SM. (2009). Effect of Tremella fuciformis Berk on anti stress activities during long-term and short-term in mice. Korean Journal of Biotechnology and Bioengineering. 24:131-139.
21 Ko MS. (2012). The growth level of hair follicles and hairs about stress-induced mice of Tremella fuciformis Berk. Journal of the Korean Society of Cosmetology. 18:1158-1165.
22 Lee MK, Kim DH, Park TS and Son JH. (2015). Antioxidant and anti-wrinkling effects of extracts from Vitex trifolia L. Journal of Applied Biological Chemistry. 58:125-129.   DOI
23 Li H, Lee HS, Kim SH, Moon BK and Lee C. (2014). Antioxidant and anti-inflammatory activities of methanol extracts of Tremella fuciformis and its major phenolic acids. Journal of Food Science. 79:C460-C468.   DOI
24 Park TS, Kim DH, Kwon OJ and Son JH. (2014). A study on biological activities of fermented jujube and grape. Korean Journal of Microbiology and Biotechnology. 42:106-113.   DOI
25 Liu JJ and Fisher DE. (2010). Lighting a path to pigmentation: Mechanisms of MITF induction by UV. Pigment Cell and Melanoma Research. 23:741-745.   DOI
26 Oh YH, Kim SB, Lee GW, Kim HY, Shim MJ, Rho HS, Lee HS, Lee MW, Lee UY and Lee TS. (2006). The immunomodulatory and antitumor effects of crude polysaccharides extracted from Tremella fuciformis. The Korean Journal of Mycology. 34:105-111.   DOI
27 Olivares C and Solano F. (2009). New insights into the active site structure and catalytic mechanism of tyrosinase and its related proteins. Pigment Cell and Melanoma Research. 22:750-760.   DOI
28 Parvze S, Kang MK, Chung WS, Cho CW, Hong MC, Shin MK and Bae HS. (2006). Survey and mechanism of skin depigmenting and lightening agents. Phytotherapy Research. 20:921-934.   DOI
29 Seo SY, Sharma VK and Sharma N. (2003). Mushroom tyrosinase: Recent prospects. Journal of Agricultural and Food Chemistry. 51:2837-2853.   DOI
30 Shi ZW, Liu Y, Xu Y, Hong YR, Liu Q, Li XL and Wang ZG. (2014). Tremella polysaccharides attenuated sepsis through inhibiting abnormal $CD4^+CD25^{high}$ regulatory T cells in mice. Cellular Immunolgy. 288:60-65.   DOI
31 Slominski A, Tobin DJ, Shibahara S and Wortsman J. (2004). Melanin pigmentation in mammalian skin and its hormonal regulation. Physiological Reviews. 84:1155-1228.   DOI
32 Sohn SH, Lee SW, Shin YS, Kim HD, Yang SO, Kim SY and Kim YO. (2013). The effect of cosmetic on anti-wrinkle of acer mono Sap. Korean Journal of Medicinal Crop Sciences. 21:262-267.   DOI