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http://dx.doi.org/10.7783/KJMCS.2015.23.5.385

Qualitative and Quantitative Analysis of Dibenzocyclooctadiene Lignans for the Fruits of Korean "Omija" (Schisandra chinensis)  

Kim, Heon Woong (National Academy of Agricultural Science, RDA)
Shin, Jae Hyeong (National Academy of Agricultural Science, RDA)
Lee, Min Ki (National Academy of Agricultural Science, RDA)
Jang, Ga Hee (National Academy of Agricultural Science, RDA)
Lee, Sung Hyeon (National Academy of Agricultural Science, RDA)
Jang, Hwan Hee (National Academy of Agricultural Science, RDA)
Jeong, Seok Tae (National Academy of Agricultural Science, RDA)
Kim, Jung Bong (National Academy of Agricultural Science, RDA)
Publication Information
Korean Journal of Medicinal Crop Science / v.23, no.5, 2015 , pp. 385-394 More about this Journal
Abstract
Background : Dibenzocyclooctadiene lignans are secondary metabolites present abundantly in the fruits belonging to the genus Schisandra. According to previous studies, Schisandra lignans exhibit anti-inflammatory, anti-cancer and anti-diabetic properties, as well as an inhibitory effect on platelet aggregation. Therefore, establishing the Korean "Omija" (Schisandra chinensis) as a lignan-rich source, in addition to identifying and quantifying the lignans, is extremely valuable. Methods and Results : Dibenzocyclooctadiene lignans were analyzed with liquid chromatography using diode array detection/mass spectrometry, from methanol extracts subsequently identified by a constructed chemical library of 50 lignans. A total of 27 components of lignan including gomisin S were identified, of which schisandrin, gomisin A, gomisin N, deoxyschisandrin, ${\gamma}$-schisandrin, and schisandrin C were identified as the major components in the Korean Omija, Schisandra chinensis. These compounds were divided into two groups, S-biphenyl and R-biphenyl based on the configurations of the stereoisomers structures with contents of 661.7 and 1350.1mg per 100 g dry weight, respectively. The total lignan content averaged 2011.4mg per 100 g dry weight, of which schisandrin and gomisin N comprised the majority (771.8 and 420.5mg per 100 g dry weight respectively). Conclusions : Lignans which are present in high quantities in the ripe fruit of Schisandra chinensis are important functional compounds that play a major role in the prevention and treatment of human diseases.
Keywords
Schisandra chinensis; Lignan; LC-MS;
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