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http://dx.doi.org/10.7783/KJMCS.2015.23.2.144

Effect of Immature Citrus sunki Peel Extract on Neuronal Cell Death  

Ko, Woon Chul (Department of Biology, Jeju National University)
Lee, Sun Ryung (Department of Biology, Jeju National University)
Publication Information
Korean Journal of Medicinal Crop Science / v.23, no.2, 2015 , pp. 144-149 More about this Journal
Abstract
The peel of Citrus sunki exhibits multiple biological activities such as anti-oxidant, anti-inflammation and anti-obesity, but little is known about neurodegeneration-related activities. In this study, we investigated the protective effect of ethanolic extract from both immature and mature Citrus sunki peel on neuronal cell death. Treatment of the neuroblastoma cell line SH-SY5Y with $MPP^+$, an inducer of Parkinson disease model, increased cell death in a dose dependent manner. Increased levels of active caspase-3 and cleaved PARP were detected. Treatment with immature Citrus sunki peel extract significantly reduced $MPP^+$-induced neurotoxicity. Cytoprotection with immature Citrus sunki peel extract was associated with a decrease in caspase-3 activation and PARP cleavage. In contrast, mature Citrus sunki peel extract had no significant effects. These data suggest that immature Citrus sunki peel extract may exert anti-apoptotic effect through the inhibition of caspase-3 signaling pathway on $MPP^+$-induced neuronal cell death.
Keywords
Citrus sunki; Apoptosis; Parkinson Disease; $MPP^+$;
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Times Cited By KSCI : 5  (Citation Analysis)
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