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http://dx.doi.org/10.7783/KJMCS.2014.22.4.262

Inhibitory Effects of Complex of Mulberry Extract on Degenerative Arthritis  

Seo, Hyeong Ho (Research Center of Ben's Lab Co., Ltd.)
Jeong, Jong Moon (Department of Life Science, The University of Suwon)
Publication Information
Korean Journal of Medicinal Crop Science / v.22, no.4, 2014 , pp. 262-269 More about this Journal
Abstract
Complex of mulberry extract (CME) is composed of extracts of mulberry (Morus alba L.) fruit, mulberry leaves and black beans (Glycine max (L.) Merr.). In this study, we investigated prevention effects of CME on degenerative arthritis. The $SC_{50}$ value of DPPH radical scavenging by CME was $158.49{\pm}11.35{\mu}/mL$. We found that CME significantly reduced the production of nitric oxide (NO) and protein expression of cyclooxygenase-2 (COX-2) in RAW 264.7 cells which were activated by LPS. Experiments using animal model of degenerative arthritis showed that CME (400 mg/kg body weight) inhibited the production of TNF-${\alpha}$ (77.5%) and IL-$1{\beta}$ (95.0%). Furthermore, it was observed that CME reduced to 85.9% of paw edema induced by carrageenan. These results suggest that CME could improve degenerative arthritis.
Keywords
Mulberry; Black Beans; Arthritis; Edema; Nitric Oxide; Cyclooxygenase-2;
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Times Cited By KSCI : 13  (Citation Analysis)
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