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http://dx.doi.org/10.7783/KJMCS.2014.22.3.177

Improvement of Cholesterol and Blood Pressure in Fruit, Leaf and Stem Extracts from Black Raspberry in vitro  

Lee, Min Jung (Gochang Black Raspberry Research Institute)
Lee, Su Jung (Gochang Black Raspberry Research Institute)
Choi, Hye Ran (Gochang Black Raspberry Research Institute)
Lee, Jung Hyun (Gochang Black Raspberry Research Institute)
Kwon, Ji Wung (Gochang Black Raspberry Research Institute)
Chae, Kyu Seo (Gochang Black Raspberry Research Institute)
Jeong, Jong Tae (Gochang Black Raspberry Research Institute)
Lee, Tae Bum (Gochang Black Raspberry Research Institute)
Publication Information
Korean Journal of Medicinal Crop Science / v.22, no.3, 2014 , pp. 177-187 More about this Journal
Abstract
We compared effects of fruit, leaf, and stem extracts from black raspberry on improvement of cholesterol and blood pressure in HepG2 and HUVEC cells, respectively. Cholesterol secretion was inhibited by water extracts of unripe fruit and stem, but not leaf of black raspberry in HepG2 cells. Also, water extracts of unripe fruit, leaf, and stem reduced HMG-CoA reductase activity. Furthermore, nitric oxide production and expression of angiotensin-converting enzyme (ACE) protein were regulated by extracts of fruit, leaf, and stem of black raspberry in HUVEC cells. Overall, the rank order according to the improving level of cholesterol and hypertension is as follows: stem > fruit > leaf. In addition, various polyphenol compounds displayed inhibitory effects of HMG-CoA reductase activity and ACE expression. Thus, these data suggested that leaf and stem as wells as fruit of black raspberry can be used as useful food resources for reduction of cholesterol and blood pressure.
Keywords
Black Raspberry; Cholesterol; Hypertension; Polyphenol Compounds; Nitric Oxide;
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Times Cited By KSCI : 8  (Citation Analysis)
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