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http://dx.doi.org/10.7783/KJMCS.2013.21.6.433

Cultivation Characteristics and Variation of Artemisinin Contents by Harvest Time of Artemisia annua L. Distributed in Korea  

Lee, Jeong Hoon (Department of Herbal Crop Research, NIHHS, RDA)
Lee, Sang Hoon (Department of Herbal Crop Research, NIHHS, RDA)
Park, Chun Geun (Department of Herbal Crop Research, NIHHS, RDA)
Park, Chung Berm (Department of Herbal Crop Research, NIHHS, RDA)
Kim, Ok Tae (Department of Herbal Crop Research, NIHHS, RDA)
Choi, Ae Jin (Department of Herbal Crop Research, NIHHS, RDA)
Kim, Yong Joo (Department of Herbal Crop Research, NIHHS, RDA)
Cha, Seon Woo (Department of Herbal Crop Research, NIHHS, RDA)
Publication Information
Korean Journal of Medicinal Crop Science / v.21, no.6, 2013 , pp. 433-438 More about this Journal
Abstract
This study was conducted to obtain the basic data for using the Artemisia anuua as a new economic crop, thus Artemisia anuua was investigated their cultivation characteristics, yield, and variation of artemisinin contents by planting density and harvesting times. Seed characteristics of A. anuua have observed micro-size, and their germination optimum temperature was at 15 to 20 celsius degree. Planting density on the yield of A. anuua was increased high density better than low density. The highest yield was planted in the space of $30{\times}10$cm. Moreover, optimum harvesting time of A. anuua was investigated in early september and a periods of most highly detected artemisinin was time of before and after blooming of A. anuua.
Keywords
Artemisia annua L; Cultivation Characteristics; Planting Density; Havesting Time; Artemisinin;
Citations & Related Records
Times Cited By KSCI : 14  (Citation Analysis)
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1 Kim CG, Im DJ, Yu HS and Lee ST. (1994). effect of planting density on the growth and yield of Ligusticum chuanxiong Hort. Korean Journal of Medicinal Crop Science. 2:26-31.   과학기술학회마을
2 Kim DH, Park CB and Kim JY. (2010). Effect of propagation method, planting density, amount of nitrogen fertilizer and cropping years on growth and yield of Asparagus cochinchinensis(Lour). Merr. Korean Journal of Medicinal Crop Science. 18:93-97.   과학기술학회마을
3 Kim MS, Chung BJ, Park GC, Park TD, Kim SC and Shim JH. (1998). Effect of planting density on the growth characteristics and root yield of Achyranthes japonica N. Korean Journal of Medicinal Crop Science. 6:137-141.   과학기술학회마을
4 Klayman DL. (1985). Qinghaosu(artemisinin): Antimalarial drug from China. Science. 228:1049-1055.   DOI
5 Kwon BS, Shin JS, Hyan KH and Shin JS. (2002) Effects of row width and plant spacing within row on yield in Scutellaria baicalensis George. Korean Journal of Plant Resources. 15:77-80.   과학기술학회마을
6 Lee JH, Park CB, Park CG and Moon SG. (2010). A phylogenetic analysis of Korean Artemisia L. based on ITS sequences. Korean Journal of Plant Resources. 23:293-302.   과학기술학회마을
7 Lee JH, Park CB, Park CG, Son YD and Moon SG. (2010). Studies on major agronomic characteristics of korean Artemisia annua L. Korean Journal of Medicinal Crop Science. 18:46-50.   과학기술학회마을
8 Lee JH. (2009). A taxonmy study of the genus Artemisia to develop medicinal resources in Korea. Ph. D. Thesis. Kyungsung University. p.1-233.
9 Lee HA, Hong SH, Han SJ and Kim OJ. (2011). Antimicrobial effects of the extract of Galla rhois on the long-term swine clinical trial. The Korean Society of Veterinary Clinics. 28:1-6.   과학기술학회마을
10 Lee JY and An BJ. (2010). Whitening and anti-wrinkle effects of Prunus persica Flos. Journal of Applied Biological Chemistry. 53:154-161.   과학기술학회마을   DOI   ScienceOn
11 Lim JR, Choo BK, Park CB, Kim DH, Choi SJ and Choi YG. (2004). Germination and growth characteristics in defferent sowing date of Artemisia capillaris Thunb. Korean Journal of Medicinal Crop Science. 12:295-299.
12 Ohgami Y, Elstad CA, Chung E, Shirachi DY, Quock RM and Lai HC. (2010) Effect of hyperbaric oxygen on the anticancer effect of artemisinin on molt-4 human leukemia cells. Anticancer Research. 30:4467-70.
13 Oh S, Kim BJ, Singh NP, Lai H and Sasaki T. (2009). Synthesis and anti-cancer activity of covalent conjugates of artemisinin and a transferrin-receptor targeting peptide. Cancer Letters. 274:33-39.   DOI   ScienceOn
14 Park JS. (1981). Effect of row-width and plant-spacing within row on yield in safflower, Carthamus tinctorius L. Korean Journal of Crop Science. 26:357-362.   과학기술학회마을
15 Park YJ and Chung YO. (1996). Studies on the characteristics of seed germination of Lycoris genera. Korean Journal of Medicinal Crop Science. 4:163-171.   과학기술학회마을
16 Rita B, Benedetta I, Stefano P, Giancarlo M, Franco FV and Anna RB. (2008). Distribution of artemisinin and bioactive flavonoids from Artemisia annua L. during plant growth. Biochemical Systematics and Ecology. 36:340-348.   DOI   ScienceOn
17 Ryu SN. (2008). Bioactive constituents and utilities of ganghwayakssuk (Artemisia princeps Pamp). The Journal of the Korean Society of International Agriculture. 20:308-314.   과학기술학회마을
18 Ryu JH, Kim RJ, Lee SJ, Kim IS, Lee HJ and Sung NJ. (2011). Nutritional properties and biological activities of Artemisia annua L. Journal of the Korean Society of Food Science and Nutrition. 40:163-170.   과학기술학회마을   DOI   ScienceOn
19 Ryu JH, Lee SJ, Kim MJ, Shin JH, Kang SK, Cho KM and Sung NJ. (2011). antioxidant and anticancer activities of Artemisia annua L. and determination of functional compounds. Journal of the Korean Society of Food Science and Nutrition. 40:509-516.   과학기술학회마을   DOI   ScienceOn
20 Ryu IH and Kwon TO. (2012). The antioxidative effect and ingredients of oil extracted from Schizandra chinensis seed. Korean Journal of Medicinal Crop Science. 20:63-71.   과학기술학회마을   DOI   ScienceOn
21 Van NFCW, Vande CSRF, Maes L, Goossens A, Inze D, Van BJ and Deforce DLD. (2006). Quantitation of artemisinin and its biosynthetic precursors in Artemisia annua L. by high performance liquid chromatography-electrospray quadrupole timeof-flight tandemmass spectrometry. Journal of Chromatography A. 1118:180-187.   DOI   ScienceOn
22 Yand SA, Pyo BS, Kim SM and Lee KI. (2012). Antibacterial activity and nitric oxide production inhibitory activity of the extract and its fractions from the leaves of Prunus sargentii. Korean Journal of Medicinal Crop Science. 20:63-71.   과학기술학회마을   DOI   ScienceOn
23 Ferreira JFS, Simon JE and Janick J. (1995). Developmental studies of Artemisia annua: Flowring and artemisinin production under greenhouseand field conditions. Planta Medica. 61:167-170.   DOI   ScienceOn
24 Abdin MZ, Israr M, Rehman RU and Jain SK. (2003). Artemisinin, anovel antimalarial drug: Biochemical and molecular approaches for enganced production. Planta Medica. 69:289-299.   DOI   ScienceOn
25 Banyai W, Mii M and Supaibulwatana K. (2011). Enhancement of artemisinin content and biomass in Artemisia annua by eogenous GA3 treatment. Plant Growth Regulation. 63:45-54.   DOI
26 Bhakuni RS, Jain DC, Sharma RP and Kumar S. (2001). Secondary metabolites of Artemisia annua and their biological activity. Current Science. 80:35-48.
27 Choi HJ, Kim EJ, Han MJ, Baek IN, Kim DH, Jung HG and Kim NJ. (2007). Hepatoprotective effect of fermented Artemisia princeps Pampanini by lactic acid bacteria. Korean Journal of Pharmacognosy. 38:245-253.   과학기술학회마을
28 Choi SR, Ju IO, You DH, Song YE, Jang I and Ryu J. (2007). Changes of major components and growth characteristics according to harvesting times of Artemisia capillaris Thunberg. Korean Journal of Medicinal Crop Science. 15:189-193.   과학기술학회마을
29 Firestone GL and Sundar SN. (2009) Anticancer activities of artemisinin and its bioactive derivatives. Expert Reviews in Molecular Medicine. 11:e32.   DOI   ScienceOn
30 Gonzalez FA, Qu G, Zhou LL, Sarevitz CH, Shurtleff JL and Xie DY. (2011). Characterization of development and artemisinin biosynthesis in self-pollinated Artemisia annua plants. Planta. 234:685-697.   DOI   ScienceOn
31 Hien TT and White NJ. (1993). Qinghaosu. Lancet. 341:603-608.   DOI   ScienceOn
32 Hwang TE. (2009). Changes in antioxidant activity during growth of Artemisia iwayomogi. Korean Journal of Medicinal Crop Science. 17:286-292.   과학기술학회마을