Overexpression of Farnesyl Diphosphate Synthase by Introducing CaFPS Gene in Panax ginseng C. A. Mey.
![]() |
Park, Hong Woo
(Department of Herbal Crop Research, NIHHS, RDA)
Kim, Ok Tae (Department of Herbal Crop Research, NIHHS, RDA) Hyun, Dong Yun (Department of Herbal Crop Research, NIHHS, RDA) Kim, Yong Bum (Department of Herbal Crop Research, NIHHS, RDA) Kim, Jang Uk (Department of Herbal Crop Research, NIHHS, RDA) Kim, Young Chang (Department of Herbal Crop Research, NIHHS, RDA) Bang, Kyong Hwan (Department of Herbal Crop Research, NIHHS, RDA) Cha, Seon Woo (Department of Herbal Crop Research, NIHHS, RDA) Choi, Jae Eul (College of Agriculture & Life Sciences, Chungnam National University) |
1 | Choi KT. (2008). Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng C. A. Meyer. Acta Pharmacologica Sinica. 29:1109-1118. DOI ScienceOn |
2 | Chen DT, Ye HC and Li GF. (2000). Expression of a chimeric farnesyl diphosphate synthase gene in Artemisia annua L. transgenic plants via Agrobacterium tumefaciens-mediated transformation. Plant Science. 155:179-185. DOI ScienceOn |
3 | Chung YY, Lee MG, Chung CM and Jo JS. (1998). Comparison of plant growth and morphological characteristics among the Korean ginseng, the American ginseng and the bamboo ginseng. Journal of Ginseng Research. 22:147-153. 과학기술학회마을 |
4 | Cunillera N, Boronat A and Ferrer A. (1997). The Arabidopsis thaliana FPS1 gene generates a novel mRNA that encodes a mitocondrial farnesyl-diphosphate synthase isoform. The Journal of Biological Chemistry. 272:15381-15388. DOI ScienceOn |
5 | Cunillera N, Boronat A and Ferrer A. (2000). Spatial and temporal patterns of GUS expression directed by 5’regions of the Arabidopsis thaliana farnesyl diphosphate synthase genes FPS1 and FPS2. Plant Molecular Biology. 44:747-758. DOI ScienceOn |
6 | Doh ES, Chang JP, Lee KH and Seong NS. (2010). Ginsenoside change and antioxidation activity of fermented ginseng. Korean Journal of Medicinal Crop Science. 18:255-265. 과학기술학회마을 |
7 | Ehlting J, Sauveplane V, Olry A, Ginglinger JF, Provart NJ and Reichhart DW. (2008). An extensive (co-)expression analysis tool for the cytochrome P450 superfamily in Arabidopsis thaliana. BMC Plant Biology. 8:1-19. DOI ScienceOn |
8 | Gaffe J, Causse M, Vidal A, Stamitti-Bert L, Carde JP and Gallusci P. (2000). LEFPS1, a thomato farnesyl pyrophosphate gene highly expressed during early fruit development. Plant Physiology. 123:137-1362. |
9 | Gillis CN. (1997). Panax gineng pharmacology: Anitricoxidelink?. Biochemical Pharmacology. 54:1-8. DOI ScienceOn |
10 | Han JY, In JG, Kwon YS and Choi YE. (2010). Regulation of ginsenoside and phytosterol biosynthesis by RNA interferences of squalene epoxidase gene in Panax ginseng. Phytochemistry. 71:36-46. DOI ScienceOn |
11 | Hayashi H, Huang PY and Inoue K. (2003). Up-regulation of soyasaponin biosynthesis by methyl jasmonate in cultured cells of Glycyrrhiza glabra. Plant and Cell Physiology. 44:404-411. DOI ScienceOn |
12 | Hu SY. (1976). The genus Panax(Ginseng) in Chinese medicine. Economic Botany. 30:11-28. DOI ScienceOn |
13 | Kim MW, Ko SR, Choi KJ and Kim SC. (1987). Distribution of saponin various sections of Panax ginseng root and change so fits contents according to root age. Journal of Ginseng Research. 11:10-16. |
14 | Kim OT, Kim MY, Huh SM, Bai DG, Ahn JC and Hwang B. (2005). Cloning of a cDNA probably encoding oxidosqualene cyclase associated with asiaticoside biosynthesis from Centella asiatica (L.) urban. Plant Cell Reports. 24:304-311. DOI ScienceOn |
15 | Kim OT, Kim SH, Ohyama K, Muranaka T, Choi YE, Lee HY, Kim MY and Hwang B. (2010). Upregulation of phytosterol and triterpene biosynthesis in Centella asiatica hairy roots overexpressed ginseng farnesyl diphosphate synthase. Plant Cell Reports. 29:403-411. DOI |
16 | Kim YS, Han JY, Lim SL and Choi YE. (2009). Ginseng metabolic engineering: Regulation of genes related to ginsenoside biosynthesis. Journal of Medicinal Plants Research. 3:1270-1276. |
17 | Kwon YD and Choi HH. (2006). Analysis of international competitiveness of Chinese ginseng in comparison with Korean ginseng. Research Institute for Agricultural Sciences and Technology. Chungnam National University. 33:43-56. |
18 | Livak KJ and Schmittgen TD. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2CT method. Methods. 25:402-408. DOI ScienceOn |
19 | Lairson LL, Henrissat B, Davies GJ and Withers SG. (2008). Glycosyl-transferases: Structures, functions, and mechanisms. Annual Review Biochemistry. 77:521-555. DOI ScienceOn |
20 | Lee MH, Jeong JH, Seo JW, Shin CG, Kim YS, In JG, Yang DC, Yi JS and Choi YE. (2004). Enhanced triterpene and phytosterol biosynthesis in Panax ginseng overexpressing squalene synthase gene. Plant and Cell Physiology. 45:976-984. DOI ScienceOn |
21 | Lichtenthaler HK. (1999). The1-deoxy-D-xylulose-5-phosphate pathway of isoprenoid biosynthesis in plants. Plant Molecular Biology. 50:47-65. |
22 | Lu G, Zou Q, Guo D, Zhuang X, Yu X, Xian X and Cao J. (2007). Agrobacterium tumefaciens-mediated transformation of Narcissus tazzeta var. chinensis. Plant Cell Reports. 26:1585-1593. DOI |
23 | Manzano D, Fernandez-Busquets X, Schaller H, Gonzandez V, Boronat A, Arro M and Ferrer A. (2004). The metabolic imbalance under lying lesion for mationin Arabidopsis thaliana farnesyl diphosphate synthase(isoform1s) leads to oxidative stress and is triggered by the developmental decline of endogenous HMGR activity. Planta. 219:982-992. DOI ScienceOn |
24 | Masferrer A Arro M, Manzano D, Schaller H, Fernandez V, Boronat A,Arro M, Fernadez B, Cunillera N, Boronat A and Ferrer A. (2002). Overexpression of Arabidosis thaliana farnesyl diphosphate synthase(FPS1S) in transgenic Arabidopsis induces a cell death/senescence-like response and reduced cytokinin levels. The Plant Journal. 30:123-132. DOI ScienceOn |
25 | Meesapyodsuk D, Balsevich J, Reed DW and Covello PS. (2007). Saponin biosynthesis in Saponaria vaccaria: cDNAs encoding ß-amyrin synthase and a triterpene carboxylic acid glucosyltransferase. Plant Physiology. 143:959-969. |
26 | Rohmer M. (2003). Mevalonate-independent methylerythritol phosphate pathway for isoprenoid biosynthesis. Elucidation and distribution. Pure and Applied Chemistry. 75:375-387. DOI ScienceOn |
27 | Murashige T and Skoog F (1962) A revised medium for rapid growth and bioassays with tobacco tissues. Physiologia Plantarum. 15:473-497. DOI |
28 | Nam KY, Park JD and Choin JE. (2011). Radioprotective potential of Panax ginseng: Current status and future prospectives. Korean Journal of Medicinal Crop Science. 19:287-299. 과학기술학회마을 DOI ScienceOn |
29 | Proctor JTA and Bailey WG. (1987). Ginseng: Industry, botany and culture. Horticultural Reviews. 9:187-236. |
30 | Sambrook J, Fritsch EF and Maniatis T. (1989). Molecular cloning. A Laboratory Manual(2nd ed.). Cold Spring Harbor Laboratory Press. Cold Spring Harbor. New York, USA. p.931-958. |
31 | Scaglione F, Cattaneo G, Alessandria M and Cogo R. (1996). Efficacy and safety of the standardized ginseng extract G 115 for potentiating vaccination against common cold and/or influenza syndrome. Drugs under Experimental and Clinical Research. 22:65-72. |
32 | See DM, Broum N, Sah lL and Till JG. (1997). In vitro effects of Echinacea and ginseng on natural killer and antibodydependent cell cytotoxicity in healthy subjects and chronicfatique syndrome or acquired immunodeficiency efficiency syndrome patients. Immunopharmacology. 35:229-235. DOI ScienceOn |
33 | Schuler MA and Werck-Reichhart D. (2003). Functional genomics of P450s. Annual Review of Plant Biology. 54:629-637. DOI |
34 | Suzuki H, Achnine L, Xu R, Matsuda SPT and Dixon RA. (2002). A genomic approach to the early stages of triterpene saponin biosynthesis in Medicago truncatula. The Plant Journal. 32:1033-1048. DOI ScienceOn |
35 | Vogler BK, Pittler MH and Ernst E. (1999). The efficacy of ginseng. A systematic review of randomized clinical trials. European Journal of Clinical Pharmacology. 55:567-575. DOI ScienceOn |
36 | Takahashi M. (1992). Anti-stress effect of ginseng on the inhibition of the development of morphine tolerance in stressed mice. Japanese Journal of Pharmacology. 59:399-404. DOI |
37 | Yu KW, Gao WY, Son SH and Paek KY. (2000). Improvement of ginsenoside production bt jasmonic acid and some other elicitors in hairy root culture of ginseng(Panax ginseng C. A. Meyer). In Vitro Cellular and Developmental Biology. 36:424-428. DOI ScienceOn |
38 | Verpoorte R, Heijden VD, Hoopen HJ and Memelink J. (1998). Metabolic engineering for the improvement of plant secondary metabolite production. Plant Tissue Culture and Biotechnology. 4:3-20. |
39 | Wen J and Zimmer EA. (1996). Phylogeny and biogeography of Panax L. (the ginseng genus, Araliaceae): Inferences from ITS sequences of nuclear ribosomal DNA. Molecular Phylogenetics and Evolution. 6:167-177. DOI ScienceOn |
40 | Wu Y, Chen Y, Liang X and Wang X. (2006). An experimental assessment of the factors influencing Agrobacterium-mediated transformation in tomato. Russian Journal of Plant Physiology. 53:252-284. DOI |
41 | Yamunadevi M, Wesely EG and Johnson M. (2011). Phytochemical studies on the terpenoids of medicinally important plant Aerva lanata L. using HPTLC. Asian Pacific Journal of Tropical Biomedicine. 1:220-225. DOI ScienceOn |
42 | Zwenger S and Basu C. (2008). Plant terpenoids: Applications and future potentials. Biotechnology and Molecular Biology Reviews. 3:1-7. |
43 | Chen D, Ye H and Li G. (2000). Expression of a chimeric farnesyl diphosphate synthase gene in Artemisia annua L. transgenic plants via Agrobacterium tumefaciens-mediated transformation. Plant Science. 155:179-185. DOI ScienceOn |
44 | Ahn IO, Lee SS, Lee JH, Lee MJ and Jo BG. (2008). Comparison of ginsenoside contents and pattern similarity between root parts. Korean Journal of Breeding Science. 32:15-18. 과학기술학회마을 DOI ScienceOn |
![]() |