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http://dx.doi.org/10.7783/KJMCS.2013.21.1.1

Buckwheat Extract Increases Resistance to Oxidative Stress and Lifespan in Caenorhabditis elegans  

Kim, Chul Kyu (Department of Medical Biotechnology, Soonchunhyang University)
Park, Sang Kyu (Department of Medical Biotechnology, Soonchunhyang University)
Publication Information
Korean Journal of Medicinal Crop Science / v.21, no.1, 2013 , pp. 1-6 More about this Journal
Abstract
Buckwheat (Fagopyrum esculentum) has been known for having strong anti-oxidant, anti-mutagenic, and anti-carcinogenic activities. The free radical theory of aging, also known as the oxidative stress theory of aging, claims that cellular oxidative damage accumulated with time is a major causal factor of aging. In the present study, we investigated the effect of buckwheat extracts on resistance to oxidative stress and aging using Caenorhabditis elegans as a model system. Survival under an oxidative-stress condition induced by paraquat increased markedly following 500mg/L buckwheat extracts treatment, suggesting lower cellular oxidative damage by buckwheat extracts. A lifespan assay also revealed that treatment of buckwheat extracts significantly extended both the mean and maximum lifespan in C. elegans. Interestingly, this lifespan-extension by buckwheat extracts was not accompanied by reduced fertility. These findings suggest that buckwheat extracts can confer longevity phenotype to C. elegans through its strong anti-oxidant activity and support the aging theory which emphasizes a pivotal role of oxidative stress during aging.
Keywords
Buckwheat; Oxidative Stress; Lifespan; Fertility; C. elegans;
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Times Cited By KSCI : 2  (Citation Analysis)
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