Browse > Article
http://dx.doi.org/10.7783/KJMCS.2012.20.4.245

Suppressive Effect of Acanthopanax sessiliflorus Extract on the DNA and Cell Damage by Dieldrin  

Ryu, A-Reum (Department of Medical Biotechnology, Soonchunhyang University)
Kim, Ji-Hae (Department of Medical Biotechnology, Soonchunhyang University)
Lee, Mi-Young (Department of Medical Biotechnology, Soonchunhyang University)
Publication Information
Korean Journal of Medicinal Crop Science / v.20, no.4, 2012 , pp. 245-250 More about this Journal
Abstract
Dieldrin, one of the organochlorine pesticides (OCPs), induced the damages in neuroblastoma cells and DNA damages in lymphocytes. The ethanol extracts of A. sessiliflorus leaves were examined for the suppressive effects on the dieldrin-induced cell damages. Moreover, the extract was used to test whether it might inhibit the oxidative DNA damage of lymphocytes using Comet assay. The cell and DNA damage by dieldrin were suppressed in vitro upon treating A. sessiliflorus extract. This result suggests that A. sessiliflorus extract might be useful to reduce dieldrin toxicity.
Keywords
Dieldrin; Acanthopanax; Cell damage; DNA damage;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
연도 인용수 순위
1 Wang X, Hai CX, Liang X, Yu SX, Zang W and Li YL. (2010). The protective effects of Acanthopanax senticosus Harms aqueous extracts against oxidative stress: role of Nrf2 and antioxidant enzymes. Journal of Ethnopharmacology. 127:424-432.   DOI
2 Noroozi M, Angerson WJ and Lean ME. (1998). Effects of flavonoids and vitamin C on oxidative DNA damage to human lymphocytes. The American Journal of Clinical Nutrition. 67:1210-1218.   DOI
3 Rowland GA, Bausch AR and Grannas AM. (2011). Photochemical processing of aldrin and dieldrin in frozen aqueous solutions under arctic field conditions. Environmental Pollution. 159:1076-1084.   DOI
4 Sawada H, Miyakoshi M, Isoda S, Ida Y and Shoji J. (1993). Saponins from leaves of Acanthopanax sieboldianus. Phytochemistry. 34:1117-1121.   DOI   ScienceOn
5 Schlaud M, Seidler A, Salje A, Behrendt W, Schwartz FW, EndeM, Knoll A and Grugel C. (1995). Organochlorine residues in human breast milk: analysis through a sentinel practice network. Journal of Epidemiology and Community Health. 49:17-21.   DOI
6 Seo YN, Kim JJ, Sung KS and Lee MY. (2010). Effect of Acanthopanax extract on the DNA and erythrocyte damage induced by herbicides. Journal of the Korea Academia- Industrial Cooperation Society. 11:4922-4927.   DOI
7 Shi L, Chen J, Yang J, Pan T, Zhang S and Wang Z. (2010). MiR-21 protected human glioblastoma U87MG cells from chemotherapeutic drug temozolomide induced apoptosis by decreasing Bax/Bcl-2 ratio and caspase-3 activity. Brain Research. 1352:255-264.   DOI
8 Singh NP, McCoy MT, Tice RR and Schneider EL. (1988). A simple technique for quantifitation of low levels of DNA damage in individual cells. Experimental Cell Research.175:184-191.   DOI   ScienceOn
9 Slotkin TA and Seidler FJ. (2010). Oxidative stress from diverse developmental neurotoxicants: antioxidants protect against lipid peroxidation without preventing cell loss. Neurotoxicology and Teratology. 32:124-131.   DOI
10 Kim JS, Seo YC, Choi WY, Kim HS, Kim BH, Shin DH, Yoon CS, Lim HW, Ahn JH and Lee HY. (2011). Enhancement of antioxidant activities and whitening effect of acer mono sap through nano encapsulation processes. Korean Journal of Medicinal Crop Science. 19:191-197.   DOI
11 Lee SJ, Kim EK, Oh HJ, Kwon HJ, Hwang JW, Moon SH, Jeon BT, Park PJ and Lim BO. (2011). Free radical scavenging activity and protective effect against H2O2-induced stress in neuronal cells of enzymatic extracts from Sarcodon aspratus. Korean Journal of Medicinal Crop Science. 19:77-82.   DOI
12 Kim SK, Kim YG, Lee MK, Han JS, Lee JH and Lee HY. (2000). Comparison of biological activity according to extracting solvents of four Acanthopanax root bark. Korean Journal of Medicinal Crop Science. 8:21-28.
13 Kim YO, Cho DH, Chung HJ, Kim JH, Chang SY, Yook CS, Yang KS and Oh OJ. (1999). Effects of lupane-triterpenoids on mitogen-induced proliferation of lymphocytes. Yakhak Hoeji. 43:208-213.
14 Kitazawa M, Anantharam V and Kanthasamy AG. (2001). Dieldrin-induced oxidative stress and neurochemical changes contribute to apoptopic cell death in dopaminergic cells. Free Radical Biology and Medicine. 31:1473-1485.   DOI
15 Lee YJ, Chung HY, Kwak HK and Yoon S. (2008). The effects of A. senticosus supplementation on serum lipid profiles, biomarkers of oxidative stress, and lymphocyte DNA damage in postmenopausal women. Biochemical and Biophysical Research Communications. 35:44-48.
16 Lin QY, Jin LJ, Cao ZH, Li HQ and Xu YP. (2008). Protective effect of Acanthopanax senticosus extract against endotoxic shock in mice. Journal of Ethnopharmacology. 118:495-502.   DOI
17 Lopez-Espinosa MJ, Granada A, Carreno J, Salvatierra M, Olea-Serrano F and Olea N. (2007). Organochlorine pesticides in placentas from Southern Spain and some related factors. Placenta. 28:631-638.   DOI
18 Hartley JM, Spanswick VJ, Gander M, Giacomini G, Whelan J, Souhami RL and Hartley JA. (1999). Measurement of DNA cross-linking in patients on ifosfamide therapy using the single cell gel electrophoresis (comet) assay. Clinical cancer research : an official journal of the American Association for Cancer Research. 5:507-512.
19 Hong JH, Cha YS and Rhee SJ. (2009). Effects of the cellcultured Acanthopanax senticosus extract on antioxidative defense system and membrane fluidity in the liver of type 2 diabetes mouse. Journal of Clinical Biochemistry and Nutrition. 45:101-109.   DOI
20 Heusinkveld HJ and Westerink RH. (2012). Organochlorine insecticides lindane and dieldrin and their binary mixture disturb calcium homeostasis in dopaminergic PC12 cells. Environmental Science and Technology. 46:1842-1848.   DOI
21 Hoyer AP, Grandjean P, Jorgensen T, Brock JW and Hartvig HB. (1998). Organochlorine exposure and risk of breast cancer. Lancet. 352:1816-1820.   DOI   ScienceOn
22 Jorgenson JL. (2001). Aldrin and dieldrin: a review of research on their production, environmental deposition and fate, bioaccumulation, toxicology, and epidemiology in the United States. Environmental Health Perspectives. 109:113-139.   DOI
23 Jung HJ, Nam JH, Choi J, Lee KT and Park HJ. (2005). Antiinflammatory effects of chiisanoside and chiisanogenin obtained from the leaves of Acanthopanax chiisanensis in the carrageenan- and Freund's complete adjuvant-induced rats. Journal of Ethnopharmacology. 97:359-367.   DOI   ScienceOn
24 Kataoka R, Takagi K, Kamei I, Kiyota H and Sato Y. (2010).Biodegradation of dieldrin by a soil fungus isolated from a soil with annual endosulfan applications. Environmental Science and Technology. 44:6343-6349.   DOI
25 Kaushik P and Kaushik G. (2007). An assessment of structure and toxicity correlation in organochlorine pesticides. Journal of Hazardous Materials. 143:102-111.   DOI   ScienceOn
26 Fleming L, Mann JB, Bean J, Briggle T and Sanchez-Ramos JR. (1994). Parkinson's disease and brain levels of organochlorine pesticides. Annals of Neurology. 36:100-103.   DOI   ScienceOn
27 Bae EA, Yook CS, Oh OJ, Chang SY, Nohara T and Kim DH. (2001). Metabolism of chiisanoside from Acanthopanax divaricatus var. albeofructus by human intestinal bacteria and its relation to some biological activities. Biological and Pharmaceutical Bulletin. 24:582-585.   DOI   ScienceOn
28 Choi GP, Chung BH, Lee DI, Lee HY, Lee JH and Kim JD. (2002). Screening of inhibitory activities on angiotensin converting enzyme from medicinal plants. Korean Journal of Medicinal Crop Science. 10:399-402.
29 Diamanti-Kandarakis E, Bourguignon JP, Giudice LC, Hauser R, Prins GS, Soto AM, Zoeller RT and Gore AC. (2009). Endocrine-disrupting chemicals: an endocrine society scientific statement. Endocrine Reviews. 30:293-342.   DOI
30 Fujikawa T, Miguchi S, Kanada N, Nakai N, Ogata M, Suzuki I and Nakashima K. (2005). Acanthopanax senticosus Harms as a prophylactic for MPTP-induced Parkinson's disease in rats. Journal of Ethnopharmacology. 97:375-381.   DOI   ScienceOn
31 Gonzalez M, Miglioranza KS, Aizpún de Moreno JE and Moreno VJ. (2003). Occurrence and distribution of organochlorine pesticides (OCPs) in tomato (Lycopersicon esculentum) crops from organic production. Journal of Agricultural and Food Chemistry. 51:1353-1359.   DOI
32 Hara J. (2001). The effect of oxygen on chemical dechlorination of dieldrin using iron sulphides. Chemosphere. 82:1308-1313.