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http://dx.doi.org/10.7783/KJMCS.2012.20.2.094

Effect of Aqueous Extract of Guava (Psidium guajava L.) Leaves on the Oral Glucose Tolerance Test and Inhibition of Glycoside Hydrolase  

Choi, Su-Min (Erom R&D Center)
Kim, Joong-Hark (Erom R&D Center)
Chung, Ji-Sang (Erom R&D Center)
Kim, Hwa-Young (Erom R&D Center)
Chang, Hye-Eun (Erom R&D Center)
Hwang, Sung-Joo (Erom R&D Center)
Hong, Seong-Gil (Erom R&D Center)
Publication Information
Korean Journal of Medicinal Crop Science / v.20, no.2, 2012 , pp. 94-100 More about this Journal
Abstract
Guava ($Psidium$ $guajava$) contain a great deal of polyphenol compound and work on the treatment of $Diabetes$ $mellitus$ effectively. In this study, the bioactivities of aqueous extract (GLEx) of guava leaf were investigated. Total phenolic contents of GLEx was 266.9 mg tan/g. The effects of GLEx on digestive enzymes, ${\alpha}$-amylase, maltase and sucrase were investigated. $IC_{50}$ values of GLEx against ${\alpha}$-amylase, maltase and sucrase were 0.65 mg/$m{\ell}$, 2.0 mg/$m{\ell}$ and 3.5 mg/$m{\ell}$ respectively. The effect of GLEx on oral glucose tolerance test (OGTT) was performed in normal ICR mouse, control (dstilled water) and GLEx (aqueous extract of Guava leaf) were co-administered orally with glucose, showed reducing effect on the blood glucose level. The guava is likely to useful for prevention or improvement of hyperglycemia by lowering the blood glucose level and inhibiting glycoside hydrolase activity.
Keywords
Guava; Psidium guajava; Polyphenol; Glycoside Hydrolase; Diabetes;
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Times Cited By KSCI : 4  (Citation Analysis)
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