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http://dx.doi.org/10.7783/KJMCS.2011.19.6.464

Effect of Solubility of Thiamine Dilauryl Sulfate Solution through the Manufacture of the Nano Paticles on Antifungal Activity  

Seo, Yong-Chang (Medical & Bio-Material Research Center and Department of Biomaterials Engineering, Kangwon National University)
Choi, Woon-Yong (Department of Biomaterials Engineering, Kangwon National University)
Lee, Choon-Geun (Department of Biomaterials Engineering, Kangwon National University)
Cho, Jeong-Sub (DooSan EcoBizNet)
Yim, Tae-Bin (DooSan EcoBizNet)
Jeong, Myoung-Hoon (DooSan EcoBizNet)
Kim, Sung-Il (Gangwon Agricultural Research & Extension Services)
Yoon, Won-Byung (Department of Food Science and Biotechnology, Kangwon National University)
Lee, Hyeon-Yong (Department of Biomaterials Engineering, Kangwon National University)
Publication Information
Korean Journal of Medicinal Crop Science / v.19, no.6, 2011 , pp. 464-471 More about this Journal
Abstract
Conventional Thiamine Dilauryl Sulfate (TDS) powder has a low stability. In order to solve this problem, this study was performed to improve the solubility of TDS. The process for enhance solubility of TDS was nano grinding mill and ultrasonic dispersion process. TDS paticle was manufactured to nano size through nano grinding mill process. The size of TDS nanoparticle was measured as average 220 nm by DLS. And The TDS nanoparticle in water solution manufactured through ultrasonic dispersion process. The TDS nanoparticle in water solution was showed the highest solubility with 40% ethanol. These results was increased the concentration of TDS from 200 ppm to 240 ppm in water solution. The TDS nanoparticle in water solution showed diameter of Colletotrichum gloeosporioides growth with smaller than about 1.56 cm compared to the TDS paticle in water solution at same concentration. Also, TDS nanoparticle in water solution showed growth inhibition activity as 59.2% with higher than about 10% compared to the TDS paticle water solution in same concentration. Finally, TDS nanoparticle in water solution was increased solubility through nano grinding mill and ultrasonic dispersion process. Also, the increase of concentration in TDS nanopaticle in water solution according to solubility enhancement lead to an result enhancement of antifungal activity. Consequently, we suggested that the TDS nanoparticle in water solution was more effective than TDS particle in water solution owing to the sub-cellular particle size, ability to persistence and targeting to cell membrane of Colletotrichum gloeosporioides. Furthermore we expected the applicating possibility with bio pesticide.
Keywords
Thiamine Dilauryl Sulfate; Nanopaticle Solution; Solubility; Antifungal Activity; Biopesticide;
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Times Cited By KSCI : 7  (Citation Analysis)
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