Browse > Article
http://dx.doi.org/10.7783/KJMCS.2011.19.6.426

Study on the Anti-inflammatory Effect of Kaempferol and Kaempferol Rhamnosides Isolated from Hibiscus cannabinus L.  

Lee, Keun-Ha (R&D Center, Morechem Co., Ltd.)
Cho, Young-Long (R&D Center, Morechem Co., Ltd.)
Joo, Chul-Gue (R&D Center, Morechem Co., Ltd.)
Joo, Yeon-Jeong (R&D Center, Morechem Co., Ltd.)
Kwon, Sun-Sang (R&D Center, Morechem Co., Ltd.)
Park, Chung (R&D Center, Morechem Co., Ltd.)
Publication Information
Korean Journal of Medicinal Crop Science / v.19, no.6, 2011 , pp. 426-434 More about this Journal
Abstract
In this study, to evaluate the anti-inflammatory effects of kaempferol and its rhamnosides isolated from Hibiscus cannabinus L. leaves, we investigated UVB-induced inhibitory effects on inflammatory reaction by measuring the cytokine as the prostaglandin ($PGE_2$), interleukine-6 (IL-6) and interleukine-8 (IL-8). We investigated the inhibitory effects of kaempferol and its rhamnosides on TARC (thymus and activation-regulated chemokine) and $PGE_2$. Kaempferol and ${\alpha}$-rhamnoisorobin showed inhibition activity of TARC generated to compared to positive control. Kaempferol, ${\alpha}$-rhamnoisorobin and afzelin Inhibited the release of $PGE_2$. Also, only kaempferol significantly inhibited interleukine-6 (IL-6), interleukine-8 (IL-8) among UVB-induced inflammatory cytokine.
Keywords
Kaempferol; Kaempferol Rhamnosides; Anti-inflammatory Effect; Hibiscus cannabinus L.; Cytokine;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
연도 인용수 순위
1 Cheon MS, Yoon TS, Choi GY, Kim SJ, Lee AY, Moon BC, Choo BK and Kim HK. (2009). Comparative study of extracts from rhubarb on inflammatory activity in raw 264.7 cells. Korean Journal of Medicinal Crop Science. 17:109-114.
2 Yoon TS, Cheon MS, Kim SJ, Lee AY, Moon BC, Chun JM, Choo BK and Kim HK. (2010). Evaluation of solvent extraction on the anti-inflammatory efficacy of Glycyrrhiza uralensis. Korean Journal of Medicinal Crop Science. 18:28-33.
3 Jin HI, Lee BR, Lim KJ, Trishna D, Shin HM and Lim BO. (2011). Anti-inflammatory effects of Prunus mune mixture in colitis induced by dextran sodium sulfate. Korean Journal of Medicinal Crop Science. 19: 16-23.   DOI
4 Chen Q, Koga T, Uchi H, Hara H, Terao H, Moroi Y, Urabe K and Furue M. (2002). Propionibacterium acnes-induced IL-8 production may be mediated by NF-kB activation in human monocytes, Journal of Dermatological Science. 29:97-103.   DOI   ScienceOn
5 Vowels BR, Yang S and Leyden JJ. (1995). Induction of proinflammatory cytokines by a soluble factor of Propionibacterium ances: Implications for chronic inflammatory acne. Infection and Immunity. 63:3158-3165.
6 Mandal PK, Freiter EM, Baqsby AL, Robertson FM and McMurray JS. (2011). Selective cyclooxygenase-2 inhibitor. Bioorganic & Medical Chemistry Letters. 21:6071-6073.   DOI   ScienceOn
7 Dovle T, Chen Z, Muscoli C, Obeid LM and Salvemini D. (2011). Intraplantar-injected ceramide in rats induces hyperalgesia through an NF-kB and p38 kinase-dependent cyclooxygenase 2/prostaglandin E2 pathway. The FASEB Journal. 25:2782-2791.   DOI   ScienceOn
8 Jin CW, Eom SH, Park HJ, Ghimeray AK, Yu CY and Cho DH. (2009). Antioxidant activity of Hibiscus cannabinus L. leaves in different growth time. Korean Journal of Medicinal Crop Science. 17:21-25.
9 Boller S, Soldi C, Marques MC, Santos EP, Cabrini DA, Pizzolatti MG, Zampronio AR and Otuki MF. (2009). Antiinflammatory effect of crude extract and isolated compounds from Baccharis illinita DC in acute skin inflammation. Journal of Ethnopharmacology. 130:262-266.
10 Fang SH, Rao YK and Tzeng YM. (2005). Inhibitory effects of flavonol glycosides from Cinnamomum osmopholeumon inflammatory mediators in LPS/IFN-γ-activatedmurine macrophages. Bioorganic & Medicinal Chemistry. 13:2381-2388.   DOI   ScienceOn
11 Tapiero H, Tew KD, Ba GN and Mathe G. (2002). Polyphenols: do they play a role in the prevention of human pathologies? Biomedicine and Pharmacotherapy. 56:200-207.   DOI   ScienceOn
12 Regasini LO, Vellosa JC, Silva DH, Furlan M, de Oliveira OM, Khalil NM, Brunetti IL, Young MC, Barreiro EJ and Bolzani VS. (2008). Flavonols from Pterogyne nitens and their evaluation as myeloperoxidase inhibitors. Phytochemistry. 69:1739-1744.   DOI   ScienceOn
13 Guha M and Mackman N. (2001). LPS induction of gene expression in human monocytes. Cell Signalling. 13:85-94.   DOI   ScienceOn
14 Lesslauer W, Tabuchi H, Gentz R, Brockhaus M, Schlaeger EJ and Grau G. (1991). Recombinant soluble tumor necrosis factor receptor proteins protect mice from lipopolysaccharideinduced lethality. European Journal of Immunology. 21:2883-2886.   DOI   ScienceOn
15 De Melo GO, Malvar Ddo C, Vanderlinde FA, Rocha FF, Pires PA, Costa EA, de Matos LG, Kaiser CR and Costa SS. (2009). Antinociceptive and anti-inflammatory kaempferol glycosides from Sedumdendroideum. Journal of Ethnopharmacology. 12:4228-4232.
16 Jorge AP, Horst H, de Sousa E, Pizzolatti MG and Silva FR. (2004). Insulinomimetic effects of kaempferitrin on glycaemia and on 14C-glucose uptake in rats oleusmuscle. Chmico-Biological Interactions. 14:989-996.
17 Vishnu Prasad CN, Suma Mohan S, Banerji A and Gopalakrishnapillai A. (2009). Kaempferitrin inhibits GLUT4 translocation and glucose uptake in 3T3-L1 adipocytes. Biochemical and Biophysical Research Communications. 380:39-43.   DOI   ScienceOn
18 Tzeng YM, Chen K, Rao YK and Lee MJ. (2009). Kaempferitrin activates the insulin signaling pathway and stimulates secretion of adiponectin in 3T3-L1 adipocytes. European Journal of Pharmacologica Neerlandica. 60:727-734.
19 Rothwell JA, Day AJ and Morgan MR. (2005). Experimental determination of octanol-water partition coefficients of quercetin and related flavonoids, Journal of Agricultural and Food Chemistry. 53:4355-4360.   DOI   ScienceOn
20 Ross D, Mendiratta S, Qu ZC, Cobb CE and May JM. (1998). Ascorbate 6-palmitate protects human erythrocytes from oxidative damage. Free Radical Biology & Medicine. 26:81-89.
21 Zuo Z, Zhang L, Zhou L, Chang Q and Chow M. (2006). Intestinal absorption of hawthorn flavonoids - in vitro, in situ and in vivo correlations. Life Science. 79:2455-2462.   DOI   ScienceOn
22 O'Leary KA, Day AJ, Needs PW, Sly WS, O'Brien NM and Williamson G. (2001). Flavonoid glucuronides are substrates for human liver ?-glucuronidase. FEBS Letters. 503:103-106.   DOI   ScienceOn
23 Navarro-Nunez L, Castillo J, Lozano ML, Martinez C, Benavente-Garcia O, Vicente V and Rivera J. (2009). Thromboxane $A^{2}$ receptor antagonism by flavonoids: structureactivity relationships. Journal of Agricultural and Food Chemistry. 57:1589-1594.   DOI   ScienceOn