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http://dx.doi.org/10.7783/KJMCS.2011.19.1.016

Anti-Inflammatory Effects of Prunus mume Mixture in Colitis Induced by Dextran Sodium Sulfate  

Jin, Hai-Lan (College of Biomedical & Health Science, Department of Applied Biochemistry, Konkuk University)
Lee, Bo-Ram (College of Biomedical & Health Science, Department of Applied Biochemistry, Konkuk University)
Lim, Kyung-Jik (Chungju High School)
Debnath, Trishna (College of Biomedical & Health Science, Department of Applied Biochemistry, Konkuk University)
Shin, Heung-Mook (Department of Physiology, Collage of Oriental Medicine, Dongguk University)
Lim, Beong-Ou (College of Biomedical & Health Science, Department of Applied Biochemistry, Konkuk University)
Publication Information
Korean Journal of Medicinal Crop Science / v.19, no.1, 2011 , pp. 16-23 More about this Journal
Abstract
This study was conducted to investigate the anti-inflammatory effects of Pruns mume, Schisandra chinensis, Chaenomeles sinensis-- Prunus mume mixtrue (PM) treatment on colitis induced in mice by dextran sodium sulfate (DSS) treatment. A total of 25 male BALB/c mice (average weight $20.7\;{\pm}\; 1.6 \;g$) were divided into 5 treatment groups and fed a commercial diet (A), PM administration (B), commercial diet + induced colitis by DSS (C), PM administration + induced colitis by DSS (D) and sulfasalazine + induced colitis by DSS (E). We found that PM treatment (D) and sulfasalazine (E) decreased the expression of $TNF-{\alpha}$ and COX-2 compared to the DSS-induced colitis group (C). The expression of IL-4, STAT6, $IFN-{\gamma}$, STAT1 was decreased in group D and group E compared to the colitis group (C), COX-2 and STAT1 were more decreased in group D. The serum IgE levels decreased in the PM treatment groups (C and D) compared to the non-PM treatment groups (A and B) although there was no significant difference between the PM treatment groups. It is notable that a therapeutic application of the PM extracts ameliorated DSS-induced colitis in mice.
Keywords
Dextran Sodium Sulfate (DSS); Prunus mume; $TNF-{\alpha}$; COX-2;
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