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Effects of Achyrantes japonica on Carrageenan-Induced Arthritis Rat Model  

Kim, Young-Ock (Department of Herbal Crop Research, NIHHIS, RDA)
Lee, San-Won (Department of Herbal Crop Research, NIHHIS, RDA)
Lee, Seung-Eun (Department of Herbal Crop Research, NIHHIS, RDA)
Publication Information
Korean Journal of Medicinal Crop Science / v.17, no.6, 2009 , pp. 470-474 More about this Journal
Abstract
Achyrantes japonica (AJ) has been used to treat edema and arthritis in the traditional Korean medicine. To elucidate the anti-inflammatory and anti-nociceptive effects of ethanol extract of AJ, the carrageenan-induced paw edema using a plethysmometer and thermal hypersensitivity using the plantar test were measured. Ibuprofen was used as a control drug. Treatment with AJ (200mg/kg p.o.) significantly reduced paw edema, compared to the carrageenan - treated rats. In the plantar test, the thermal withdrawal latency in AJ - treated group was significantly increased than the carrageenan - treated group. The results indicate that AJ could have be the anti-inflammatory and anti-nociceptive properties.
Keywords
Achyrantes japonica; Inflammation; Nociception; Paw Edema;
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Times Cited By KSCI : 1  (Citation Analysis)
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