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Comparative Effect on Anti-Inflammatory Activity of the Phellinus linteus and Phellinus linteus Grown in Germinated Brown Rice Extracts in Murine Macrophage RAW 264.7 Cells  

Jeoung, Young-Jun (Dept. of Life Science, College of Biomedical & Health Science, Konkuk University)
Choi, Se-Young (Dept. of Life Science, College of Biomedical & Health Science, Konkuk University)
An, Chi-Sun (Dept. of Life Science, College of Biomedical & Health Science, Konkuk University)
Jeon, Yun-Hee (Dept. of Life Science, College of Biomedical & Health Science, Konkuk University)
Park, Dong-Ki (Dept. of Bioscience and Biotechnology, Konkuk University)
Lim, Beoung-Ou (Dept. of Life Science, College of Biomedical & Health Science, Konkuk University)
Publication Information
Korean Journal of Medicinal Crop Science / v.17, no.2, 2009 , pp. 97-101 More about this Journal
Abstract
The present study describes the preliminary evaluation of the anti-inflammatory activities of Phellinus linteus (PL) and Phellinus linteus Grow in Germinated Brown Rice (BRPL). In order to effectively screen for anti-inflammatory agents, we first examined the extracts' inhibitory effects on the expression of pro-inflammatory cytokines activated with lipopolysaccharide. Moreover, we examined the inhibitory effects of the PL and BRPL extracts on pro-inflammatory factors such as NO, iNOS, $TNF-{\alpha}$ and $IFN-{\gamma}$ in murine macrophage RAW 264.7 cells. NO production and iNOS expression was significantly augmented in LPS treated cell, the production of NO and iNOS was greater in the BRPL than in the PL group. In addition, protein and mRNA levels of $TNF-{\alpha}$ and $IFN-{\gamma}$ in BRPL showed relatively more potent pro-inflammatory-activity inhibition compared to that of PL. These results suggest that BRPL may have significant effects on inflammatory factors, and may be a potential anti-inflammatory therapeutic materials.
Keywords
Phellinus linteus; Germinated brown rice; Anti-Inflammation; Nitric oxide; $TNF-{\alpha}$; $IFN-{\gamma}$;
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Times Cited By KSCI : 3  (Citation Analysis)
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