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Comparative Study of Extracts from Rhubarb on Inflammatory Activity in Raw 264.7 Cells  

Cheon, Myeong-Sook (Center of Herbal Resources Research, Korea Institute of Oriental Medicine)
Yoon, Tae-Sook (Center of Herbal Resources Research, Korea Institute of Oriental Medicine)
Choi, Go-Ya (Center of Herbal Resources Research, Korea Institute of Oriental Medicine)
Kim, Seung-Ju (Center of Herbal Resources Research, Korea Institute of Oriental Medicine)
Lee, A-Yeong (Center of Herbal Resources Research, Korea Institute of Oriental Medicine)
Moon, Byeong-Cheol (Center of Herbal Resources Research, Korea Institute of Oriental Medicine)
Choo, Byung-Kil (Center of Herbal Resources Research, Korea Institute of Oriental Medicine)
Kim, Ho-Kyoung (Center of Herbal Resources Research, Korea Institute of Oriental Medicine)
Publication Information
Korean Journal of Medicinal Crop Science / v.17, no.2, 2009 , pp. 109-114 More about this Journal
Abstract
Rhubarb is the well-known and frequently used herbal medicine for the treatment of constipation, inflammation, and cancer. As described in the Korea and Chinese Pharmacopoeia, rhubarb consists of the roots and rhizomes of Rheum palmatum, R. officinale, and R. tanguticum. However, the pharmacological differences among rhubarb have not been scientifically established. In the present study, we investigated and compared the inhibitory effects of 70% ethanolic extracts from R. palmatum (RPE), R. officinale (ROE), R. nobile (RNE), and R. franzenbachii (RFE) on the production of inflammatory mediators, nitric oxide (NO), prostaglandin $E_2$ ($PGE_2$), interlukin-1beta ($IL-1{\beta}$), and tumor necrosis factor-alpha ($TNF-{\alpha}$) in RAW 264.7 macrophage cells. ROE, RNE, and RFE significantly inhibited the release of NO, $PGE_2$, $IL-1{\beta}$, and $TNF-{\alpha}$. RPE significantly reduced the release of $IL-1{\beta}$, but not NO, $PGE_2$, and $TNF-{\alpha}$. Overall, RFE was found to inhibit the release of $PGE_2$ and $IL-1{\beta}$, to a far greater degree than RPE, ROE, and RNE. Our results indicate that RFE possess the strongest anti-inflammatory activity among 4 tested rhubarb.
Keywords
Anti-inflammation; Inflammatory Mediators; Rheum franzenbachii; Rheum nobile; Rheum officinale; Rheum palmatum;
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Times Cited By KSCI : 5  (Citation Analysis)
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