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Antimicrobial Agent from Schima wallichii ssp. liukiuensis against Candida spp.  

Shin, Kuem (Division of Research Planning and Coordination, Korea Forest Research Institute)
Min, Ji-Yun (Division of Environmental Forest Science, Gyeongsang National Univ.)
Kang, Seung-Mi (Division of Forest Research, Gyeongsangnam-do Forest Envirionmental Institude)
Park, Dong-Jin (Division of Environmental Forest Science, Gyeongsang National Univ.)
Song, Hyun-Jin (Division of Environmental Forest Science, Gyeongsang National Univ.)
Kwon, Oh-Woong (Division of Research Planning and Coordination, Korea Forest Research Institute)
Yang, Jae-Kyung (Division of Environmental Forest Science, Gyeongsang National Univ.)
Karigar, Chandrakant S. (Department of Biochemistry, Bangalore University)
Choi, Myung-Suk (Division of Environmental Forest Science, Gyeongsang National Univ.)
Publication Information
Korean Journal of Medicinal Crop Science / v.17, no.1, 2009 , pp. 61-67 More about this Journal
Abstract
This study carried out development of a natural antimicrobial agent from Schima wallichii ssp. liukiuensis. Compound I exhibiting potent antimicrobial activity against Candida spp. was isolated from the methanol extracts of Schima wallichii ssp. liukiuensis. The structure of I identified as a sterol glycoside consisted of a trisaccharide and ${\alpha}_1$-sitosterol. Trisaccharide composed of L-rhamnose, D-galactose and D-glucose residues. The antimicrobial activity of I was selective on yeast rather than bacteria or other fungi. Compound I was demonstrated to be ineffective against toxicity to mouse liver cells where as protective to human dermal fibroblast cells at low concentrations. Thus, it is reasonable to expect a sterol glycoside (I) as a valuable alternative for synthetic antifungal.
Keywords
Schima wallichii ssp. liukiuensis; Antimicrobial; Sterol glycoside; Candida spp.;
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