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Enhancement of Immuno Modulatory Activities of Rubus coreanus Miquel Extracts by Nano-encapsulation Process  

Han, Jae-Gun (College of Bioscience and Biotechnology, Kangwon National Univ.)
Kwon, Min-Chul (College of Bioscience and Biotechnology, Kangwon National Univ.)
Ha, Ji-Hye (College of Bioscience and Biotechnology, Kangwon National Univ.)
Jeong, Hyang-Suk (College of Bioscience and Biotechnology, Kangwon National Univ.)
Kim, Young (College of Bioscience and Biotechnology, Kangwon National Univ.)
Jeong, Myoung-Hoon (College of Bioscience and Biotechnology, Kangwon National Univ.)
Kim, Jin-Chul (College of Bioscience and Biotechnology, Kangwon National Univ.)
Lee, Hyeon-Yong (College of Bioscience and Biotechnology, Kangwon National Univ.)
Publication Information
Korean Journal of Medicinal Crop Science / v.17, no.1, 2009 , pp. 54-60 More about this Journal
Abstract
This study was performed to improve immune activities of Rubus coreanus Miquel by encapsulation of nanoparticles. Immuno-activities of R. coreanus were investigated through aqueous extracts associated with process of water at $60^{\circ}C$. It showed high promotion of human B and T cells growth about 50%, compared to the case of other conditions. The secretion of IL-6 and TNF-${\alpha}$ was also enhanced as $2.44{\times}10^{-4}$pg/cell and $1.94{\times}10^{-4}$pg/cell, results by adding nano samples. NK cell activation was improved up to 29% higher than the conventional extraction process. The secretion of NO from macrophage showed 14.9 ${\mu}M$ on the nano-encapsulation process extracts, which was higher than others. The size of nanoparticles was in the range of 50${\sim}$300 nm, which can effect the penetration into the cells. It was clearly observed by real time confocal microscope.
Keywords
Rubus coreanus Miquel; Eatable Nano-Encapsulation; Immuno modulatory Activities;
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Times Cited By KSCI : 6  (Citation Analysis)
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