Browse > Article

Screening for Human ACAT-1 and ACAT-2 Inhibitory Activity of Edible Plant Extracts  

Lee, Dae-Young (Plant Metabolism Research Center and Institute of Life Science & Resources, KyungHee University)
Jeong, Tae-Sook (National research Laboratory of Lipid Metabolism & Atherosclerosis, Korea research Institute of Bioscience and Biotechnology)
Lyu, Ha-Na (Plant Metabolism Research Center and Institute of Life Science & Resources, KyungHee University)
Bang, Myun-Ho (Plant Metabolism research Center and Institute of Life Science & resources, KyungHee University)
Hong, Yoon-Hee (Plant Metabolism Research Center and Institute of Life Science & Resources, KyungHee University)
Lee, Youn-Hyung (Department of Horticultural Biotechnology, KyungHee University)
Baek, Nam-In (Plant Metabolism Research Center and Institute of Life Science & Resources, KyungHee University)
Publication Information
Korean Journal of Medicinal Crop Science / v.16, no.5, 2008 , pp. 341-348 More about this Journal
Abstract
Cholesterol acyltransferase (ACAT) catalyzes the acylation of cholesterol to cholesteryl ester with long chain fatty acids and ACAT inhibition is a useful strategy for treating hypercholesterolemia or atherosclerosis. Inhibitory effects on ACAT of the MeOH extracts prepared from 163 edible plants were evaluated. 15 species out of 163 species exhibited higher than 50% of inhibition on the hACAT-1 and 9 species exhibited higher than 50% of inhibition on the hACAT-2 activity at their concentration of $100\;{\mu}g/mL$.
Keywords
Edible Plant; Acyl-CoA: Cholesterol Acyltransferase (ACAT); Hypercholesterolemia; Atherosclerosis;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
연도 인용수 순위
1 Al-Sereiti MR, Abu-Amer KM, Sen P (1999) Pharmacology of rosemary (Rosmarinus officinalis Linn.) and its therapeutic potentials. Indian Journal of Experimental Biology 37:124-130
2 Brown MS, Dana SE, Goldstein JL (1975) Cholsterol ester formation in cultured human fibroblasts. J. Biol. Chem. 250:4025-4027
3 De Pradier E (2006) A trial of a mixture of three essential oils in the treatment of postoperative nausea and vomiting. International Journal of Aromatherapy 16:15-20   DOI   ScienceOn
4 Dommick MA, Mcguire EJ, Reindel JF, Bobrowski WF, Bocan TM, Gough AW (1993) Subacute toxicity of a novel inhibitor of Acyl-CoA: cholesterol acyltransferase in beagle dogs. Fundam. Appl. Toxicol. 20:217-224   DOI   ScienceOn
5 Frankel EN (1999) Food antioxidants and phytochemicals. Fett. Lipid 101:450-455   DOI   ScienceOn
6 Im KR, Jeong TS, Kwon BM, Baek NI, Kim SH, Kim DK (2006) Acyl-CoA: Cholesterol acyltransferase inhibitors from llex macropoda. Arch. Pharm. Res. 29: 191-194   과학기술학회마을   DOI
7 Jeong TS, Kim SU, Son KH, Kwon BM, Kim YK, Choi MU, Bok SH (1995) GERI-BP001 compounds, new inhibitors of Acyl-CoA:Cholesterol acytransferase from Aspergillus fumigatus F37. J. Antibiot. 48:751-756   DOI   ScienceOn
8 Ogata M (2004) Biological activity of eugenol. Aroma Research 5:259-262
9 Rho MC, Lee SW, Park HR, Choi JH, Kang JY, Kim K, Lee HS, Kim YK (2007) ACAT inhibition of alkamides identified in the fruits of Piper nigrum. Phytochemistry 68:899-903   DOI   ScienceOn
10 Anderson RA, Joyce C, Davis M, Reagan JW, Clark M, Shelness GS, Rudel LL (1998) Identification of a form of Acyl-CoA: Cholesterol acyltransferase specific to liver and intestine in nonhuman primates. J. Biol. Chem. 273:26747-26754   DOI   ScienceOn
11 Raghavenra H, Diwakr BT, Lokesh BR, Naidu KA (2006) Eugenol-the active principle from cloves inhibits 5-lipoxygenase activity and leukotriene-C4 in human PMNL cells. Prostaglandins Leukotrienes and Essential Fatty Acids 74:23-27   DOI   ScienceOn
12 Jun DY, Kim JS, Park HS, Han CR, Fang Z, Woo MH, Rhee IK, Kim YH (2007) Apoptogenic activity of auraptene of Zanthoxylum schinifolium toward human acute leukemia Jurkat T cells is associated with ER stress-mediated caspase-8 activation that stimulates mitochondria-dependent or - independent caspase cascade. Carcinogenesis 28:1303-1313   DOI   ScienceOn
13 Paik SY, Koh KH, Beak SM, Paek SH, Kim JA (2005) The essential oils from Zanthoxylum schinifolium pericarp induce apoptosis of HepG2 human hepatoma cells through increased production of reactive oxygen species. Biol. Pharm. Bull. 28: 802-807   DOI   ScienceOn
14 Tipton DA, Lyle B, Babich H, Dabbous MK (2003) In vitro cytotoxic and anti-inflammatory effects of myrrh oil on human gingival fibroblasts and epithelial cells. Toxicology in Vitro 17:301-310   DOI   ScienceOn
15 Conforti F, Statti G, Uzunov D, Menichini F (2006) Comparative chemical composition and antioxidant activities of wild and cultivated Laurus nobilis L. leaves and Foeniculum vulgare subsp. piperitum (Ucria) coutinho seeds. Biol. Pharm. Bull. 29:2056-2064   DOI   ScienceOn
16 Fuhrman B, Volkova N, Rosenblat M, Aviram M (2000) Lycopene synergistically inhibits LDL oxidation in combination with vitamin E, glabridin, rosmarinic acid, carnosic acid, or garlic. Antioxidants & Redox Signaling 2:491-506   DOI   ScienceOn
17 Prashar A, Locke IC, Evans CS (2006) Cytotoxicity of clove oil and its major components to human skin cells. Cell Proliferation 39:241-248   DOI   ScienceOn
18 Bainard LD, Isman MB, Upadhyaya MK (2006) Phytotoxicity of clove oil and its primary constituent eugenol and the role of leaf epicuticular wax in the susceptibility to these essential oils. Weed Science 54:833-837   DOI   ScienceOn
19 El-Ashmawy IM, Ashry KM, Salama OM (2006) Immunomodulatory effects of myrrh (Commiphora molmol) in comparison with turmeric (Curcuma longa) in mice. Alexandria Journal of Pharmaceutical Sciences 20:19-22
20 Matsuo M, Hashimoto M, Suzuki J, Iwanami K, Tomoi M, Shimomura K (1996) Difference between normal and WHHL rabbits in susceptibility to the adrenal toxicity of an Acyl-CoA: cholesterol acyltransferase inhibitor, FR145237. Toxicol. Appl. Pharmacol. 140:387-392   DOI   ScienceOn
21 Brecher P, Chan CT (1980) Properties of acyl-CoA: Cholesterol O-acyltransferase in aortic microsomes from atherosclerotic rabbits. Biochem. Biophys. Acta. 617:458-471   DOI   ScienceOn
22 Sliskovic DR, Picard JA, Krause BR (2002) 3 ACAT inhibitors: The search for a novel and effective treatment of hypercholesterolemia and atherosclerosis. Prog. Med. Chem. 39:121-171   DOI
23 Lee SE, Seong NS, Park CG, Seong JS (2002) Screening for antioxidative activity of oriental medicinal plant materials. Korean J. Medicinal Crop. Sci. 10: 171-176
24 Accad M, Smith SJ, Newland DL, Sanan DA, King LE, Linton MF, Fazio S, Farese RJ (2000) Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking Acyl CoA: cholesterol acyltransferase 1. J. Clin. Invest. 105:711-719   DOI   ScienceOn
25 Selenu MB, Carrus F, Bonsignore L (2005) Phytochemical study on Capsella bursa pastoris L. Bollettino Chimico Farmaceutico 144:66-78
26 Coses S, Novak S, Zheng Y, Myers HM, Lear SR, Sande E, Welch CB, Lusis AJ, Spancer TA, Krouse BR, Erickson SK, Farese RV (1998) ACAT-2, a second mammalian Acyl-CoA: Cholesterol acyltransferase. J. Biol. Chem. 273:26755-26764   DOI
27 Haze S, Sakai K, Gozu Y (2002) Effects of fragrance inhalation on sympathetic activity in normal adults. Japanese Journal of Pharmacology 90:247-253   DOI   ScienceOn
28 Miyamaoto K, Nomura M, Sasakura M, Matsui E, Koshiura R, Murayama T, Furukawa T, Hatano T, Yoshida T, Okuda T (1993) Antitumor activity of oenothein B, a unique macrocyclic ellagitannin. Japanese Journal of Cancer Research 84:99-103   DOI
29 Rudel LL, Lee RG, Cockman TL (2001) Acyl coenzyme A: cholesterol acyltransferase types 1 and 2: structure and function in atherosclerosis. Curr. Opin. Lipidol. 12:121-127   DOI   ScienceOn
30 Joyce CW, Shelness GS, Davis MA, Lee RG., Skinner K, Anderson RA, Rudel LL (2000) ACAT1 and ACAT2 membrane topology segregates a serine residue essential for activity to opposite sides of the endopasmic reticulum membrane. Mol. Biol. Cell 11:3675-3687   DOI
31 Han KM, Kim DH, Ahn EM, Lee YH, Chung IS, Kim DK, Kwon BM, Kim SH, Baek NI (2007) Anticoagulation and anticancer constituents from Eugenia caryophyllata Thunb. Korean J. Medicinal Crop. Sci. 15: 82-88   과학기술학회마을
32 Kim DH, Han KM, Kim DH, Chung IS, Kim DK, Kim SH, Kwon BM, Jeong TS, Park MH, Ahn EM, Baek NI (2005) Triterpenoids from the flower of Campsis grandiflora K. Schum. as human Acyl-CoA: Cholesterol acyltransferase inhibitors. Arch. Pharm. Res. 28: 550-556   과학기술학회마을   DOI
33 Zhang C (2007) Traditional Chinese medicine for treating hypertension, hyperlipidemia and arteriosclerosis. Faming Zhuanli Shenqing Gongkai Shuomingshu p. 11
34 Naito Y, Oka S, Yoshikawa T (2003) Inflammatory response in the pathogenesis of atherosclerosis and its prevention by rosmarinic acid, a functional ingredient of rosemary. ACS Symposium Series 851:208-212   DOI
35 Barla A, Topcu G, Oeksuez S, Tuemen G, Kingston David GI (2007) Identification of cytotoxic sesquiterpenes from Laurus nobilis L. Food Chemistry 104:1478-1484   DOI   ScienceOn
36 Cho KH, An S, Lee WS, Paik YK, Kim YK, Jeong TS (2003) Mass-production of human ACAT-1 and ACAT-2 to screen isoform-specific inhibitor: a different substrate specificity and inhibitory regulation. Biol. Pharm. Bull. 29:382-384   DOI   ScienceOn