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Skin-Whitening and UV-Protective Effects of Angelica gigas Nakai Extracts on Ultra High Pressure Extraction Process  

Kim, Cheol-Hee (College of Bioscience & Biotechnology, Kangwon Natl. Univ.)
Kwon, Min-Chul (College of Bioscience & Biotechnology, Kangwon Natl. Univ.)
Han, Jae-Gun (College of Bioscience & Biotechnology, Kangwon Natl. Univ.)
Na, Chun-Su (Lifetree Biotech Co. Ltd.)
Kwak, Hyeong-Geun (SKY007 Co.)
Choi, Geun-Pyo (Department of Food Processing & Bakery, Gangwon Provincial Univ.)
Park, Uk-Yeon (Department of Food Processing & Bakery, Gangwon Provincial Univ.)
Lee, Hyeon-Yong (College of Bioscience & Biotechnology, Kangwon Natl. Univ, Research Institute of Bioscience and Biotechnology, Kangwon Natl. Univ.)
Publication Information
Korean Journal of Medicinal Crop Science / v.16, no.4, 2008 , pp. 255-260 More about this Journal
Abstract
This study was performed to investigate the enhancement of UV-protection activities and skin-whitening effects from Angelica gigas Nakai extracts on ultra high pressure extraction process. Extraction at $60^{\circ}C$ treated by ultra high pressure for 15 minute and associated with ultrasofication (HPE15) was showed more than double yield, compare conventional extraction, as 12.24% (w/w) from A. gigas. Extracts of HPE15 reduced expression of MMP-1 on UV-irradiated CCD-986sk cells as 122.2% and revealed high inhibitory potency on tyrosinase as 69.4% by adding samples. Extracts of HPE15 from A. gigas showed strong inhibition effect on melanin production test by Clone M-3 cells as 82.4% by adding extracts. From the preliminary observations, we considered that the extracts from A. gigas could be potent natural materials for skin-whitening agent, and could be used as a potential anti-aging agent for the photo-damaged skin.
Keywords
Angelica gigas Nakai; Ultra High Pressure; UV Protection; Skin-Whitening;
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Times Cited By KSCI : 5  (Citation Analysis)
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