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Enhancement of Immune-Potentiation of Cichorium endivia L. by Ultrasonification Extraction Process  

Kwon, Min-Chul (College of Bioscience & Biotechnology, Kangwon National Univ.)
Han, Jae-Gun (College of Bioscience & Biotechnology, Kangwon National Univ.)
Qadir, Syed Abdul (College of Bioscience & Biotechnology, Kangwon National Univ.)
Ahn, Ju-Hee (College of Bioscience & Biotechnology, Kangwon National Univ.)
Lee, Dal-Ho (Sorak traditional foods Co.)
Lee, Hyeon-Yong (Research Institute of Bioscience and Biotechnology, Kangwon National University)
Publication Information
Korean Journal of Medicinal Crop Science / v.16, no.1, 2008 , pp. 9-15 More about this Journal
Abstract
Immune-potentiation of Chicorium endivia L. were investigated on follows extracts associated with ultrasonification process at 60 kHz and showed the highest promotion of human B and T cell growth, about $10{\sim}20%$ compared to the control. The secretion of TNF-${\alpha}$ and IL-6 was also enhanced by the addition $(0.5mg/m{\ell})$ of the extracts. NK cell activation was Improved up to 1.37 times higher than the control, through adding extracts. It was also found that extracts from C. endivia L. could yield higher nitric oxide production from macrophage than Lipopolysaccaharides (LPS). It can be concluded that, in general, the extracts treated with ultrasonification has higher immune activity than others, possibly by higher yielding immune-modulatory activity than conventional extraction process. The optimum condition for the extraction of C. endivia L. is ethanol extraction at $60{\sim}100^{\circ}C$ associated with ultrasonification.
Keywords
Chicorium endivia L.; Immune-Potentiation; Ultrasonification;
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Times Cited By KSCI : 10  (Citation Analysis)
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