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Modulation of Cytochrome P-450 Induction by Long-Term Supplementation with Korean Red Ginseng to Rats  

Lim, Heung-Bin (Department of Industrial Plant Science and Technology, College of Agriculture, Life and Environment Science, Chungbuk National University)
Publication Information
Korean Journal of Medicinal Crop Science / v.15, no.6, 2007 , pp. 437-443 More about this Journal
Abstract
This study was carried out to investigate the effect of dietary supplementation with red ginseng water-extracts on the induction of microsomal cytochrome P-450 in rats. Phenobarbital (PB) and 3-methylcholanthrene (3-MC), P-450 inducers, were administered to 3- or 12-month old rats received red ginseng extracts (25 mg/kg) from 6 weeks to 12 months for 3 days. PB and 3-MC increased levels of P-450, P-450 reductase, ethoxycoumarin O-deethylase, benzphetamine N-demethylase and glutathione-S-transferase in the liver of rats. However, chronic administration of red ginseng significantly reduced these increase of enzyme levels induced by P-450 inducers. Chronic administration of red ginseng did not affect the induction of cytochrome $b_5$ and NADH cytochrome $b_5$ reductase by P-450 inducers. It is suggested that the induction of cytochrome P-450 system in the liver in relation to xenobiotics toxicity can be modulated by long-term supplementation with Korean red ginseng to rats.
Keywords
red ginseng; enzyme induction; cytochrome P-450 inducers;
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Times Cited By KSCI : 5  (Citation Analysis)
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