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Hepatoprotective Effect of Catechin Isolated from the Root of Rosa rugosa Thunb  

Hur, Jong-Moon (Department of Oriental Medicine Resources and Research Institute of Korean Oriental Medicine, Sunchon National University)
Kim, In-Ho (Department of Oriental Medicine Resources and Research Institute of Korean Oriental Medicine, Sunchon National University)
Park, Jong-Cheol (Department of Oriental Medicine Resources and Research Institute of Korean Oriental Medicine, Sunchon National University)
Publication Information
Korean Journal of Medicinal Crop Science / v.15, no.1, 2007 , pp. 21-25 More about this Journal
Abstract
The root of Rosa rugosa has been used in folkloric medicine as a treatment agent for diabetes. In the present study, we investigated whether (+)-catechin isolated from this plant can change the activities of hepatic drug metabolizing enzymes in rats treated with bromobenzene. Pretreatment with (+)-catechin gave no effects on the activities of aminopyrine N-demethylase and aniline hydroxylase, enzymes forming toxic bromobenzene epoxide intermediates and glutathione Stransferase, an enzyme removing toxic epoxides. However, the activity of epoxide hydrolase, an enzyme detoxifying the bromobenzene toxic intermediates was mildly recovered by (+)-catechin treatment.
Keywords
Rosa rugosa; bromobenzene; (+)-catechin; hepatoprotection;
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Times Cited By KSCI : 2  (Citation Analysis)
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