Browse > Article

Screening and Extraction Condition of Anti-skin Aging Elastase Inhibitor from Medicinal Plants  

Kwak, Yoon-Jin (Dept. of Genetic Engineering, Paichai University)
Lee, Dae-Hyoung (Dept. of Genetic Engineering, Paichai University)
Kim, Na-Mi (Central Research Institute, KT & G Corporation)
Lee, Jong-Soo (Dept. of Genetic Engineering, Paichai University)
Publication Information
Korean Journal of Medicinal Crop Science / v.13, no.6, 2005 , pp. 213-216 More about this Journal
Abstract
To develop a new anti-skin aging cosmetics or functional foods by using elastase inhibitor, a potent elastase inhibitor was screened from various extracts of medicinal plants and its optimal extraction condition was investigated. Methanol extracts of Rubi fructus showed the highest elastase inhibitory activity of 85%. The elastase inhibitor of Rubi fructus was maximally extracted when it was treated with 80% methanol at $50^{\circ}C$ for 12hr and its elastase inhibitory activity $(IC_{50})$ was 0.52 mg.
Keywords
anti-skin aging cosmetics; Rubi fructus; elastase inhibitor;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 AOAC; Official methods of analysis /
[ Kenneth, H. ] /
2 Inhibitory effects of 150 plant extracts on elastase activity and their antiinflammatory effects /
[ Lee, K.K.;Kim, J.H.;Cho, J.J.;Choi, J.D. ] / Inter. J. Cosmo Sci.
3 Level of Plasma <TEX>$Elastase-{\alpha}1-Proteinase$</TEX> Inhibitor in Patients with Behcet's Disease /
[ Lee, S.H.;Shin, D.J.;Kim, D.W.;Jun, J.B.;Kim, J.C.;Chung, S.L. ] / Annals of Dermatology
4 Isolation and characterization of MMP-I inhibitor peptide from Crataegus pinnatifida bunge in fibroblast cell line HS68 cells /
[ Lee, S.Y.;An, J.H.;Cho, H.Y. ] / J. Kor. Soc. Agric. Chem. Biotechno.
5 Inactivation of Spinach Glycolat Oxidase by Arginine-Specific Reagent /
[ Lee, K.K.;Choi, J.D. ] / Kor. Biochem. J.
6 Quercetin is recovered in human plasma as conjugated derivative which retain antioxidant properties /
[ Manach, C.;Morand, C.;Crespy, V.;Demigne, C.;Texier, O.;Regerat, F.;Remesy, C. ] / FEBS Lett.
7 Skin aging and antioxidants /
[ Park, S.N. ] / J. Soc. Cosmet. Sci. Kor.
8 Structure-antioxidant activity relationships of flavonoids and phenolic acid /
[ Rice-Evants, C.A.;Miller, N.J.;Paganga, G. ] / Free Radic. BioI. Med.
9 Elastase and tryptase determination on human skin surface /
[ Voegeli, R. ] / Cosmetic & Toiletries
10 Elafin : An elastase specific inhibition of human skin /
[ Wiedow, O.J.;Schroder, M.;Christophers, E. ] / J. Biol. Chem.
11 Identification and activity of antioxidative compounds from Rubus coreanum fruit /
[ Yoon, I.J.;Cho, Y.;Kuk, J.H.;Wee, J.H.;Jang, M.Y.;Ahn, T.H.;Park, K.H. ] / Kor. J. Food Sci. Technol.
12 Food New Biomaterials, Hanlimnon /
[ Yang, H.C. ] /
13 Inhibition of human leckocyte and pocine pancreatic elastase by homologues of bovine pancreatic trypsin inhibitors /
[ James, A.E.;Timothy, D.W.;Gordon, L. ] / Biochemistry