Browse > Article

Antioxidant Effect of Flavonoids Isolated from the Root of Clematis trichotoma Nakai  

Hung, Tran Manh (College of Pharmacy, Chungnam National University)
Thuong, Phuong Thien (College of Pharmacy, Chungnam National University)
Bae, Ki-Hwan (College of Pharmacy, Chungnam National University)
Publication Information
Korean Journal of Medicinal Crop Science / v.13, no.5, 2005 , pp. 227-232 More about this Journal
Abstract
The antioxidant effect of methanol extract (ME) and water extract (WE) from Clematis trichotoma was evaluated as primary study to scavenge stable 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH), inhibited iron-induce lipid peroxidation in linoleic acid emulsion, peroxidation of liposome induced by $Fe^{3+}/H_2O_2/ascorbie$ acid, and on $Fe^{2+}/H_2O_2$ induced the mitochondrial lipid peroxidation. In secondary study, five flavonoids as luteolin (1), quercetin (2), apigenin (3), hirsutrin (4), kaempferol-3-O-glucoside were isolated (5). Among them, compounds 1 and 2 showed good activities in all the model systems. Compound 3 exhibited moderate antioxidant activities in both radical scavenging and these lipid peroxidation systems tested. Compound 4 showed significant inhibitions in liposome peroxidation and compound 5 displayed weak inhibition in all four tested systems. All the results presented herein indicate that products of C. trichotoma maybe useful in inhibiting membrane lipid peroxidation and preventing free radical-linked diseases.
Keywords
Clematis trichotoma; flavonoids; antioxidant; lipid peroxidation; free radical;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Antioxidant properties of solvent extracts from Terminalia catappa leaves /
[ Chyau, C.C.;Tsai, S.Y.;Ko, P.T.;Mau, J.L. ] / Food Chemistry
2 Hepatoprotective and free radical scavenging activities of phenolic petrosins and flavonoids isolated from Equisetum arvense /
[ Oh, H.C.;Kim, D.H.;Cho, J.H.;Kim, Y.C. ] / J. Ethnopharm.
3 Antioxidative activity of extracts from Mengkudu (Morinda citrifolia L.) root, fruit and leaf /
[ Zin, Z.M.;Hamid, A.A.;Osman, A. ] / Food Chem.
4 Protein measurement with the folin phenol reagent /
[ Lowry, O.H.;Rosebrough, N.J.;Farr, A.L.;Randall, R.J. ] / J. Bio Chem.
5 Dictionary of Traditional Medicines /
[ Kim, C.M.;Shin, M.K.;An, D.K.;Lee, K.S. ] /
6 Inhibitory effects of plant-derived flavonoids and phenolic acids on malonaldehyde formation from ethyl arachidonate /
[ Lee, K.G.;Shibamoto, T.;Takeoka, G.R.;Lee, S.E.;Kim, J.H.;Park, B.S. ] / J. Agric. Food Chem.
7 Flora of Korea /
[ Lee, Y. ] /
8 Evaluation of extracts from Gevuina avallana Hulls as antioxidants /
[ Moure, A.;Franco, D.;Sineiro, J.;Dominguez, H.;Nunez, M.J.;Lema, J.M. ] / J. Agric. Food Chem.
9 Structural requirements of flavonoids for inhibition of protein glycation and radical scavenging activities /
[ Matsuda, H.;Wang, T.;Managi, H.;Yoshikawa, M. ] / Bio. Med. Chem.
10 Antioxidative action of indole compounds during the autoxidation of linoleic acid /
[ Mitsuda, H.;Yasumoto, K.;Iwami, K. ] / Eiyo To Shok
11 Antioxidant properties of phenolic compounds /
[ Rice-Evans, C.A.;Miller, N.;Paganga, G. ] / Trends in Plant Sience
12 Protective role of Apigenin on the status of lipid peroxidation and antioxidant defense against hepatocarcinogenesis in Wistar albino rats /
[ Singh, J.P.V.;Selvendiran, K.;Banu, S.M.;Padmavathi, R.;Sakthisekaran, D. ] / Phytomedicine   ScienceOn
13 A simple screening method for antioxidants and isolation of several antioxidants produced by marine bacteria from fish and shellfish /
[ Taco, T.;Kitatani, F.;Watanabe, N.;Yagi, A.;Sakata, K. ] / Biosci. Biotech Biochem.
14 Chia seeds as a source of natural lipid antioxidants /
[ Taga, M.S.;Miller, E.E.;Pratt, D.E. ] / J. Am. Oil Chem. Soc.
15 Effects of rutin and quercetin on mitocholdrial metabolism and on ATP levels in germinating tissues of Glycine max /
[ Takahashi, L.;Sert, M.A.;Kelmer-Bracht, A.M.;Bracht, A.;Iwamoto, I. ] / Plant Physiol. Biochem.
16 Compounds of the stem of Clematis trichotoma /
[ Ham, S.B.;Kim, Y.I.;Kwon, Y.S.;Kim, C.M. ] / Kor J. Pharmacogn.
17 Vitamin E oxidation in rat liver mitochondria /
[ Ham, A.J.L.;Liebler, D.C. ] / Biochem.
18 Influence of phospholipids on the development of oxidized off flavours in cooked turkey roll /
[ Wu, T.C.;Sheldon, B.W. ] / J. Food Sci.
19 Lipid peroxides and human disease /
[ Yagi, K. ] / Chem. Phys. Lipids
20 Antioxidant activity of extracts from Du-zhong (Eucommia ulmoides) toward various lipid peroxidation models in vitro /
[ Yen, G.C.;Hsieh, C.L. ] / J. Agric Food Chem.
21 Relationship between antioxidant activity and maturity of peanut hulls /
[ Yen, G.C.;Duh, P.D.;Tsai, C.L. ] / J. Agric. Food Chem.
22 Antioxidant activities and phenolic composition of extracts from Greek oregano, Greek sage, and summer savory /
[ Exarchou, V.;Nenadis, N.;Tsimidou, M.;Gerothanassis, I.P.;Troganis, A.;Boskou, D. ] / J. Agric. Food Chem.
23 The Medicinal Plants of Korea /
[ Bae, K.H. ] /
24 Aging, cancer, and mitochondrial deterioration /
[ Cotton, D.W.K.;Roger, S. ] / Lancet
25 Antioxidant efficacy of methanolic extracts of peanut hulls in soybean and peanut oils /
[ Duh, P.D.;Yen, G.C. ] / J. Am. Oil. Chem. Soc.
26 Antioxidant activity of quercetin and myricetin in liposomes /
[ Gordon, M.H.;Roedig-Penman, A. ] / Chem. Physics Lipids.
27 Free radicals in biology and medicine /
[ Halliwell, B.;Gutteridge, J.M.C. ] /