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Cytotoxic Anthraquinones and Stilbenes from Reynoutria sachalinensis (Fr. Schm.) Nakai  

Jin, Wenyi (College of Pharmacy, Chungnam Natl. Univ.)
Na, Min-Kyun (College of Pharmacy, Chungnam Natl. Univ.)
Song, Gyu-Yong (College of Pharmacy, Chungnam Natl. Univ.)
Lee, Young-Mi (Dept. of Oriental Pharmacy, College of Pharmacy, Wonkwang Univ.)
Bae, Ki-Hwan (College of Pharmacy, Chungnam Natl. Univ.)
Publication Information
Korean Journal of Medicinal Crop Science / v.13, no.2, 2005 , pp. 80-84 More about this Journal
Abstract
Five known anthraquinones, physcion (1), I-O-methylemodin (2), emodin (3), $physcion-8-O-{\beta},-D-glucopyranoside$ (5), $emodin-8-O-{\beta},-D-glucopyranoside$ (6) and two known stilbenes, trans-resveratrol (4), $trans-resveratrol-3-O-{\beta},-D-glucopyranoside$ (7) were isolated from MeOH extract of Reynoutria sachalinensis (Polygonaceae). All structures were unambiguously established by 1D and 2D NMR and MS data and the compounds were evaluated for their cytotoxicity against L1210, HL-60, BI6F10 tumor cell lines in MTT assay. Among the compounds, trans-resveratrol (4) exhibited significant cytotoxic activity with $IC_{50}$ values of 9.2, 6.7 and $9.8\;{\mu}g/ml$, against the test cell lines respectively, but compounds 1-3 exhibited the moderate cytotoxic activity.
Keywords
Reynoutria sachalinensis; Polygonaceae; anthraquinones; stilbenes; cytotoxicity;
Citations & Related Records
Times Cited By KSCI : 6  (Citation Analysis)
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