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The Constituents Isolated from Peucedanum japonicum Thunb. and their Cyclooxygenase (COX) Inhibitory Activity  

Zheng, Mingshan (College of Pharmacy, Chungnam Natl. Univ.)
Jin, Wenyi (College of Pharmacy, Chungnam Natl. Univ.)
Son, Kun-Ho (Dept. of Food & Nutrition, Andong Natl. Univ.)
Chang, Hyeun-Wook (College of Pharmacy, Yeungnam Univ.)
Kim, Hyun-Pyo (College of Pharmacy, Kangwon Natl. Univ.)
Bae, Ki-Hwan (College of Pharmacy, Chungnam Natl. Univ.)
Kang, Sam-Sik (Natural Products Research Institute & College of Pharmacy, Seoul Natl. Univ.)
Publication Information
Korean Journal of Medicinal Crop Science / v.13, no.2, 2005 , pp. 75-79 More about this Journal
Abstract
Five coumarins, psoralen (1), scopoletin (2), isoimperatorin (4), (+)-marmesin (5) and xanthotoxin (6), three chromones, cimifugin (3), hamaudol (7) and sec-O-glucosylhamaudol (10), one sterol, daucosterol (8) and one aliphatic alcohol, galactitol (9) were isolated from the root of Peucedanum japonicum. Their chemical structures were identified by the physicochemical and spectroscopic data by comparing literature values. Among them, compounds 9 and 10 were isolated for the first time from this plant. The anti-inflammatory effects of isolated compounds were examined on cyclooxygenase (COX), compounds 1, 2 and 7 showed inhibitory activity on COX-1 with $IC_{50}$ values of 0.88, 0.27 and 0.30 mM, respectively. In the test for COX-2 activity, only compound 7 showed significant inhibitory activity with the $IC_{50}$ value of 0.57 mM. The other compounds exhibited weak inhibitory or no inhibitory activity.
Keywords
Peucedanum japonicum; coumarins; chromones; anti-inflammatory; COX-1; COX-2;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
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8 Dihydropyranocoumarins from roots of Peucedanum japonicum /
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12 Antioxidant compounds from the leaves of Peucedanum japonicum Thunb /
[ Hisamoto, M.;Kikuzaki, H.;Ohigashi, H.;Nakatani, N. ] / Journal of Agricultural and Food Chemistr
13 Monoterpene, chromone and coumarin glucosides of Diplolophium buchananii /
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14 Pharmacological activities of khellactones, compounds isolated from Peucedanum japonicum Thunb. and Peucedanum praeruptorium Dunn /
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15 Cytotoxic pyranocoumarins from roots of Peucedanum japonicum /
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16 Coumarins and antiplatelet aggregation constituents from Formosan Peucedanum japonicum /
[ Chen, I.S.;Chang, C.T.;Sheen, W.S.;Teng, C.M.;Tsai, I.L.;Duh, C.Y.;Ko, F.N. ] / Phytochemistry
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[ Choi, H.C.;Rho, T.C.;Kim, B.Y.;Ko, H.R.;Oh, W.K.;Seong, C.K.;Mheen, T.I.;Ahn, J.S.;Lee, H.S. ] / Saengyak Hakhoechi