Browse > Article

Inhibitory Activity of Plant Extracts against Prolyl Endopeptidase  

Kim, Geum-Soog (Ginseng & Medicinal Crops Division, National Institute of Crop Science, RDA)
Lee, Seung-Eun (Ginseng & Medicinal Crops Division, National Institute of Crop Science, RDA)
Lee, Hee-Ju (Dept. of Agricultural Chemistry, Kyungpook National University)
Kim, Yi-Min (Ginseng & Medicinal Crops Division, National Institute of Crop Science, RDA)
Jeon, So-Young (Dept. of Agricultural Chemistry, Kyungpook National University)
Park, Chun-Geon (Ginseng & Medicinal Crops Division, National Institute of Crop Science, RDA)
Seong, Nak-Sul (Ginseng & Medicinal Crops Division, National Institute of Crop Science, RDA)
Song, Kyung-Sik (Dept. of Agricultural Chemistry, Kyungpook National University)
Publication Information
Korean Journal of Medicinal Crop Science / v.12, no.1, 2004 , pp. 1-9 More about this Journal
Abstract
Prolyl endopeptidase (PEP) is proline-specific serine protease, cleaving peptide bonds on the biologically active neuropeptides such as substance P, vassopressin, and thyrotropin-releasing hormone and is, therefore, suggested to play important roles in learning and memory process. In this work, the inhibitory effect of plant extracts on PEP was investigated. Out of 200 plant extracts, Prunus mume, Pyrola. japonica, Hypericum ascyron, Astilbe chinensis var. typica, and Elaeagnus umbellata inhibited more than 90% of PEP activity at the concentration of 5 ppm.
Keywords
prolyl endopeptidase; inhibitory activity; plant extracts;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
연도 인용수 순위
1 Han JS， Lee JY， Baek NI， Back IW， Shin DH (2002) Isolation of growth inhibition substance on food borne microorganisms from Hypericum ascyron L. an application to food preservation Korean J. Food. Sci. Technol. 34(2):274-282
2 Kim BJ， Kim JH (1997) Biological screening of 100 plant extracts for cosmetic use (II) : anti-oxidative activity and tree radical scavenging activity. Intl. J. Cosmet Sci. 19:299-307   DOI
3 Kim KB， Kim SI， Kim JS， Song KS (1999) Prolyl endopeptidase inhibiting isoflavonoids from Puerariae Flos and some revision of their 13C-NMR assignment. J. Korean Soc. Agric. Chern. Biotechnol. 42(4):351-355
4 Kim SI， Song KS (2000) 1，2，3，4，6-pentagalloyl-，$\beta$-D glucopyranose， a prolyl endopeptidase inhibitor from moutan cortex. J. Korean Soc. Agric,. Chem. Biotechnol. 43(2):158-161   과학기술학회마을
5 Lee KH， Kwak JH， Lee KB， Song KS (1998) Prolyl endopeptidase inhibitors from Caryophylli Flos. Arch. Pharm. Res. 21(2):207-211   DOI
6 Nagai M， Ogawa K， Muraoka Y， Naganawa H， Aoyagi T， Takeuchi T (1991) Poststatin， a new inhibitor of prolyl endopeptidase， produced by Streptomyces MH534-30F3. II Structure determination and inhibitory activities. J. Antibiotics 44:956-961   DOI
7 Nakajima T， Ono Y， Kato A， Maeda]， Ohe T (1992) Y-29794-a non-peptide prolyl endopeptidase inhibitor that can penetrate into brain. Neurosci. Lett. 141:156-160   DOI   ScienceOn
8 Toda S， Obi Y， Numata K， Hamagishi Y， Tomita K， Komiyama N， Kotake C， Furumai T， Oki T (1992) Eurystatins A and B， new prolyl endopeptidase inhibitors. I. Taxonomy， production， isolation and biological activities. J. Antibiotics 45:1573-1579   DOI
9 Masters CL， Simms G， Weinman NA， Multhaup G， McDonald BL，Beyreuther K (1985) Amyloid plaque core protein in Alzheimer disease and down syndrome. Pro. Natl. Acad Sci. USA. 82:4245-4249   DOI   ScienceOn
10 Welches WR， Brosniham KB， Ferrari CM (1993) A comparison of the properties and enzymatic activities of three angiotinsin processing enzymes angiotensin converting enzyme， prolyl endopeptidase and neutral endopeptidase 24. 11. Life Sci. 52:1461-1480   DOI   ScienceOn
11 Walter R， Shlank H， Glass JD， Schwartz IL， Kerenyi TD (1971) Leucyl-glycinamide released from oxytocin by human uterine enzyme. Science 173:827-829   DOI   ScienceOn
12 Aoyagi T， Nagai M， Ogawa K， Kojima F. Okada M， Ikeda T， Hmada M， Takeuchi (1991) Postatin, a new inhibitor of prolyl endopeptidase， produced by Streptomyces viridochromogenes MH534-30F3. 1. Taxonomy， production， isolation， physico-chemical properties and biological activities. J. Antibiotics 44:949-955   DOI
13 Ichai C， Chevalier N， Delaere P， Dournaud P， Epelbaum J， Hauw JJ， Vicent JP， Cheder F (1994) Influence of regionspecific alterations of neuropeptidase content on the catabolic rates of neuropeptides in Alzheimer's disease. J. Neurochem. 62:645-655   DOI   ScienceOn
14 Kamei H， Ueki T， Obi Y， Fukagawa Y， Oki T (1992) Protective effect of eurystatin A and B， new prolyl endopeptidase inhibitors， on scopolamine-induced amnesia in rats. Japan]. Pharmacol. 60:377-380   DOI
15 Tsuru D， Yoshmoto T (1987) 抗健忘症藥の開發-プロリルエンドペプチダ-ゼ沮害劑の開發 Bio Industry 4:778-796
16 Turner AJ (1986) Processing and metabolism of neuropeptides. Essays Biochem 22:69-119
17 Jung SE， Bae JH (2002) The effect of Prunus mume extracts on the growth of HepG2 and HeLa cell lines. Korean J. Nutrition 35(4):439-445   과학기술학회마을
18 hishido Y, Furushiro M, Tanabe S, Shibata S,Hashimoto S, Yokokura T (1999) Effects of prolyl endopeptidase inhibitors and neuropeptides on delayed neuronal death in rats. Eur. J. Pharmacol. 372:135-142   DOI   ScienceOn
19 Suh YH (1992) Molecular biology of Alzheimer' s disease. Saengwhahak Nyusu 12:283-241
20 Schneider JS， Giardiniere M， Morain P (2002) Effects of the prolyl endopeptidase inhibitor S 17092 on cognitive deficits in chronic low dose MPTP-treated monkeys. Neuropsychopharmacol. 26(2):176-182   DOI   ScienceOn
21 Auld DS， Kar S， Quirion R (1998) $\beta$-amyloid peptides as direct cholinergic neuromodulators missing link? Trends Neurosci 21:43-49   DOI   ScienceOn
22 Kato A， Fukunari A， Tabira T， Shimizu T， Arahata K， Sugita HD (1997) Prevention of amyolid-like deosition by a selective prolyl endopeptidase inhibitor， Y-29794， in senescenceaccelerated mouse. J. Phamacol. Exp. Therap. 283:328-335
23 Toide K， Shinoda M， Iwamoto Y， Fujiwara T， Okamiya K， Uemura A (1997) A novel prolyl endopeptidase inhibitor， JTP-4819， with potential for treating Alzheimer's disease. ，Behav. Brain Res. 83:147-151   DOI   ScienceOn
24 Vendeville S， Goossens F， Debreu-Fontaine MA， Landry V，Davioud-Charvet ED， Grellier P， Scharpe S， Sergheraert C (2002) Comparison of the inhibition of human and Trypanosoma cruzi prolyl endopeptidases, Bioorgan. Med. Chem. 10:1719-1729   DOI   ScienceOn
25 Butterweck V， Bockers T， Korte B， Wittkowski W， Winterhoff H (2002) Long-term effects of St. John's wort and hypericin on monoamine levels in rat hypothalamus and hippocampus. Brain Res. 930:21-29   DOI   ScienceOn
26 Han JT， Lee SY， Kim KN， Baek NI (200l) Rutin， antioxidant compound isolation from the fruit of Prunus mume. J. Korean Soc. Agric. Chem. Biotechnol. 44(1):35-37
27 Yoshimoto T， Kado K， Matsubara F， Koriyama N， Kaneto H， Tsuru D (1987) Specific inhibitors for prolyl endopeptidase and their anti-amnesic effect. J. Pharmacobio-Dyn. 10:730-735   DOI
28 Seo MH， Bae JH (2002) Effect of butanol extracts from Prunus mume on the growth of Salmonella typhunrium. Korean J. Nutrition 35(9):926-931
29 Irazusta J， Larrinaga G， Gonzalez-Maeso J， Gil J， Meana J， Casis L (2002) Distribution of prolyl endopeptidase activities in rat and human brain. Neurochem. Int. 40:337-345   DOI   ScienceOn
30 Shishido Y, Furushiro M, Tanabe S, Nishiyama S, Hashimoto S, Ohno M, Yamamoto T, Watanabe S(1996) ZTTA, a post proline cleaving enzyme inhibitor, improves cerebral ischemia-induced deficits in a three-panel runway task in rats. Pharmacol. Biochem. Behav. 55:333-338   DOI   ScienceOn
31 Copani A， Sortino MA， Nicoletti F， Giuffrida Stella AM (2002) Alzheimer's disease research enters a 'new cycle' How singificant? Neurochem. Res. 27(1/2):173-176   DOI   ScienceOn
32 Toide K， Iwamoto Y， Fujiwara T， Abe H (1995) JTP-4819: a novel pr이yl endopeptidase inhibitor with potential as cognitive enhancerι J. Pharmacol. ，Exp. Therapeutics 274:1370-1378
33 김창민， 신민교， 안덕균， 이청순(완역) 1998. 중약대사전 도서출판 정담. p. 3952-3954