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Screening of 94 Plant Species Showing ACE Inhibitory Activity  

Yun, Jeong-Sik (School of Biotechnology and Bioengineering, Kangwon National University)
Chung, Byung-Hee (School of Biotechnology and Bioengineering, Kangwon National University)
Kim, Na-Young (Dept. of Food and Nutrition, Kyung Hee University)
Seong, Nak-Sul (Crop Experiment Station, RDA)
Lee, Hyeon-Yong (School of Biotechnology and Bioengineering, Kangwon National University)
Lee, Jin-Ha (School of Biotechnology and Bioengineering, Kangwon National University)
Kim, Jong-Dai (School of Biotechnology and Bioengineering, Kangwon National University)
Publication Information
Korean Journal of Medicinal Crop Science / v.11, no.3, 2003 , pp. 246-251 More about this Journal
Abstract
Angiotensin converting enzyme(ACE) belongs to the class of zinc protease and plays an important role in the regulation of blood pressure. In this experiment, we investigated the inhibitory activities of ninety four plant extracts on ACE. The extracts were prepared by water and refluxing with 70% and 100% methanol. Among the extracts, two plant extracts such as Cassia tora, Persicaria cochinchinensis Kitagawa showed more than 60% inhibitory activities, and Foeniculum vulgare Gaertner, Scutellaria baicalensis Georgl, Caragana sinica (Buchoz) Rehder, Inula britannica var. chinensis showed $45.2{\sim}49.7%$ inhibitory activities. Twenty eight plant extracts such as Hemerocallis fulva L, Camptotheca acuminata Decne, Inula britannica var. chinensis, Xanthium strumarium, Polygonatum odoratum, Phellodendron amurense Rupr, Coix lachryma-jobi var. mayuen, Prunus ansu, Hibiscus mutabilis L, Thchosanthes kirilowii, Helianthus annuus, Juglans sinensis showed $30.3{\sim}39.7%$ Inhibitory activities. These results suggest that plant extracts which contain high ACE inhibitory activities may be useful as anti-hypertension agents and to the treatment of hypertension.
Keywords
angiotensin converting enzyme; hypertension; blood pressure;
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Times Cited By KSCI : 1  (Citation Analysis)
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