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Comparison of Biological Activities of Epimedium koreanum Nakai Produced in Korea and China  

Noh, Joon-Hyun (Gangwon Agricultural Research and Extension Services)
Kim, Young-Jin (Gangwon Agricultural Research and Extension Services)
Kim, Se-Won (Gangwon Agricultural Research and Extension Services)
Lee, Jin-Ha (School of Biotechnology and Bioengineering, Kangwon National University)
Lee, Hyeon-Yong (School of Biotechnology and Bioengineering, Kangwon National University)
Publication Information
Korean Journal of Medicinal Crop Science / v.11, no.3, 2003 , pp. 195-200 More about this Journal
Abstract
This study was carried out to compare the biological activities of Epjmedium koreanum Nakai grown wild in Korea and China. The antioxidative effect of E. koreanum Nakai-extracts grown wild in Gangwondo was 78%, which was higher than that in China as 71%. The inhibition ratio of growing cancer cells was estimated as 89, 91 and 86% for human liver, lung and breast cancer cell lines, respectively in adding 0.1 g/l of ethanol extracts of E. koreanum grown in Korea. The hepatoprotective effect and Angiotensin Converting Enzyme (ACE) inhibiting effect of Korean one were also observed as 124 and 87%, respectively, which were also higher than those produced in China. There was not much difference between Korean and Chinese one in inhibiting ${\alpha}-glucosidase$ activities in all ranges of supplement. It was proved that most effective extraction solvent was mixed type as water and ethanol (1:1, v/v) to have higher biological activities from both Korean and Chinese ones.
Keywords
antioxidative; anticancer; hepatoprotective; angiotensin converting enzyme (ACE); ${\alpha}-glucosidase$; inhibiting activities;
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1 Benson AM, Cha YN, Talalay P (1979) Elevation of extrahepatic GST and epoxide hydrase activities by hydroxyanisole. Cancer Res. 39 : 2971-2977
2 Kata T, Inoue T, Ohta T, Shrisu Y (1986) Antimutagen and their modes of action. In D. H. Shankel et al. Plenum, New York 181-189
3 Kim SR, Kim JH, Kim SK (1992) Isolation and characterization of antioxidant components in Epimedium koreanum Nakai extract. Korean J. Food Sci. Technol. 24(6) : 535-540
4 Kun YP, Sook HR (1992) Inhibitory effect of green-yellow vegetables on the mutagenicity in salmonella assay system and on the growth of AZ-521 human gastric cancer cells, J. Kor. Soc. Food Nutr. 21(2) : 149-153
5 Lee GY, Jee UK (1996) Cytotoxicity, stability and antitumor activity of 5-florouracil prodrags entrapped in liposomes. Yakhak Hoeji 40(5) : 522-531
6 Tamagawa K, Iizuka S, Fukushima S, Endo Y, Komyama Y (1997) Antioxidative activity of polyphenol extracts from Barley Bran. Nippon Shokuhin Kagaku Kaishi 44(7) : 512-515   DOI   ScienceOn
7 Cha BC, Lee SB (1998) Antioxidative and free radical scavenging effects of Rhus javanica Linne. Korean J. Medicinal Crop Sci. 6(3) : 181-187
8 Kim SH, Park ES (1994) The study of prepared GE-132 on the hepatic glutathione-S-transferase activity in rat. J. Kor. Soc. Food Nutr, 23 : 581-586
9 Shin KH, Lim SS, Ahn SD, Kim SK, Park KY (1996) Difference in components of Epimedium koreanum in compliance with seasons and places of collection. Korean J. Medicinal Crop Sci. 4(4) : 321-328
10 Habig WH, Pabst JM (1974) Glutathione-S-transferase. J. BioI. Chem 22 : 7130-7139
11 Chung IM, Kim KH, Ahn JK, Ahn JS, Ahn SC (1999) Screening of Korean medicinal and food plants with antitumoral activity. Korean J. Medicinal Crop Sci. 7(1) : 37-44
12 Kwon YS, Kim MJ, Choi YH, Kwak SS (1997) Activity of antioxidative components from the stem of Acer mono Max. Korean J. Medicinal Crop Sci. 5(4) : 302-306
13 Kim SY, Park KJ, Lee WC (1998) Antiflammatory and antioxidative effects of Morus spp. fruit extract. Korean J. Medicinal Crop Sci. 6(3) : 204-209
14 Franca Z (1995) Studies on the insectidal activities of some new N-benzoyl-N'-srylureas. Pestle. Sci. 44 : 227-236