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Biological Activities of Coreopsis tinctoria Nutt. Flower Extracts  

Hwang, In-Guk (Department of Food Science and Technology, Chungbuk National University)
Kim, Hyun-Young (Department of Food Science and Technology, Chungbuk National University)
Shin, So-Lim (Department of Horticultural Science, Chungbuk National University)
Lee, Cheol-Hee (Department of Horticultural Science, Chungbuk National University)
Lee, Jun-Soo (Department of Food Science and Technology, Chungbuk National University)
Jang, Keum-Il (Department of Food Science and Technology, Chungbuk National University)
Jeong, Heon-Sang (Department of Food Science and Technology, Chungbuk National University)
Publication Information
Horticultural Science & Technology / v.28, no.5, 2010 , pp. 857-863 More about this Journal
Abstract
This study was conducted to evaluate the antioxidant activity, Angiotensin I Converting Enzyme (ACE) inhibitory activity, ${\alpha}$-glucosidase inhibitory activity, nitrate synthesis inhibitory activity, and antiproliferation inhibitory effect on ethanol extract and its solvent fractions of $Coreopsis$ $tinctoria$ Nutt. Ethyl acetate fraction was the strongest at 1,1-diphenyl-2-picryl hydrazyl (DPPH) ($IC_{50}=0.100mg{\cdot}mL^{-1}$) and 2,2'-Azino-bis-(3-ethylbenozothiazoline-6-sulfonic acid) (ABTS) (15.785 mg AA $eq{\cdot}10mg^{-1}$) radical scavenging activity, ACE (40.96% at $1mg{\cdot}mL^{-1}$), and ${\alpha}$-glucosidase ($IC_{50}=0.125mg{\cdot}mL^{-1}$) inhibitory effect among the solvent fractions. Nitrate synthesis inhibitory activity of ethanol extract, chloroform fraction, and ethyl acetate fraction effectively inhibited NO formation in a dose-dependent manner without the cytotoxic effect. Ethanol extract and its solvent fractions inhibited growth of HCT-116 colon cancer cells in a dose-dependent manner. n-Hexane fraction showed the highest antiproliferation inhibitory effect of $0.041mg{\cdot}mL^{-1}$ among fractions.
Keywords
antioxidant activity; antiproliferation inhibitory effect; ${\alpha}$-glucosidase inhibitory activity; nitrate synthesis inhibitory activity;
Citations & Related Records
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