Browse > Article
http://dx.doi.org/10.5656/KSAE.2011.09.0.39

NO and Cytokine Production due to Crysochroa fulgidissima  

Ahn, Mi-Young (Department of Agricultural Biology, National Academy of Agricultural Science, Rural Development Administration)
Kim, Soon-Ja (Department of Agricultural Biology, National Academy of Agricultural Science, Rural Development Administration)
Jeong, Hye-Kyoung (Department of Agricultural Biology, National Academy of Agricultural Science, Rural Development Administration)
Seo, Yun-Jung (Department of Agricultural Biology, National Academy of Agricultural Science, Rural Development Administration)
Park, Hae-Cheol (Department of Agricultural Biology, National Academy of Agricultural Science, Rural Development Administration)
Lee, Young-Bo (Department of Agricultural Biology, National Academy of Agricultural Science, Rural Development Administration)
Kim, Mi-Aae (Department of Agricultural Biology, National Academy of Agricultural Science, Rural Development Administration)
Publication Information
Korean journal of applied entomology / v.50, no.3, 2011 , pp. 227-233 More about this Journal
Abstract
Crysochroa fulgidissima (Bidan-beole, Spanish fly) is traditionally used as a crude drug and insecticide in the East Asia and Korea, respectively. This study investigated the effect of ethanol extract of C. fulgidissima on the NO production activity. The C. fulgidissima extract was a potent inducer of NO production in CPAE cells and a stimulator of endothelial nitric oxide synthase in a dose-dependent manner. This study also evaluated the anti-inflammatory activity of this extract by determining the level of ICAM-1, VCAM-1, and prostaglandin $E_2$ from HUVEC cells. Although C. fulgidissima extract was a potent inducer of NO production in the CPAE cells, it showed weak inhibitory effects on vascular endothelial growth factor (VEGF) production in HUVEC cells. HPLC and GC-MS analysis of the ethanol extract of C. fulgidissima revealed the presence of cantharidin.
Keywords
Crysochroa fulgidissima larvae extract; NO production; cantharidin;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Nakatani, T., K. Jinpo and N. Noda. 2007. Cantharimide dimers from the Chinese blister beetle, Mylabris phalerate Pallas, Chem. Pharm. Bull. 55(1): 92-94.   DOI   ScienceOn
2 Nikbakhtzadeh, M.R. and B. Ebrahimi. 2007. Detection of cantharidin- related compounds in Mylabris impressa (Coleoptera: Meloidae). J. Venom. Anim. Toxins incl. Trop. Dis. 13: 686-693.
3 Nikbakhtzadeh, M.R., K. Dettner, W. Boland, G. Gade, S. Dootterl. 2007. Intraspecific transfer of cantharidin within selected members of the family Meloidae (Insecta: Coleoptera). J. Insect physiol. 53: 890-899.   DOI   ScienceOn
4 Ahn, M.Y., S.R. Ryu, Y.W. Lee and Y.S. Kim. 2000. Cytotoxicity and L-amino acid oxidase activity of crude insect drugs. Arch. Pharm. Res. 23: 477-481.   과학기술학회마을   DOI
5 Ahn, M.Y., H. Lee, H.J. Shon, Y.T. Yang, K.D. Kim, H.C. park, J.S. Hwang and S.J. Hwang. 2006. In vitro effects of water and methanol extracts of Melittia inouei on cytokine production. Kor. J. Pharmacogn. 37: 110-115.   과학기술학회마을
6 Ahn, M.Y., S.H. Shim, H.K. Jeong, K.S Ryu. 2008. Purification of a dimethyladenosine compound from silkworm pupae as a vasorelaxation substance. J. Ethnopharm. 117: 115-122.   DOI   ScienceOn
7 Chen, Y.J., W.M. Chang, Y.W. Liu, C.Y. Lee, Y.H. Jang, C.D. Kuo and H.F. Liao. 2009. A small-molecule metastasis inhibitor, norcantharidin, downregulates matrix metalloprotease-9 expression by inhibiting Sp1 transcriptional activity in colorectal cancer cells. Chemico-Biological interactions 181: 440-446.   DOI   ScienceOn
8 Nims, R.W., J.F. Darbyshire, J.E. Saavedra. 1995. Colorimetric methods for the determination of nitric oxide concentration in neutral aqueous solutions. Methods 7: 48-54.   DOI   ScienceOn
9 Rothelin, R., M. Czajkpwski, M. M. O'Neill, S. D. Marlin, E. Mainolfi and V.J. Merluzzi. 1988. Induction of intercellular adhesion molecule-1 on primary and continuous cell lines by pro-infalmmatory cytokines. J. Immunol. 141: 1665-1669.
10 Sandroni, P. 2001. Aphrodisiacs past and present: a historical review, Clin Auton Res. 11: 303-307.   DOI   ScienceOn
11 Cui, Z., M.Y. Ahn, Y.B Lee and K.S. Ryu. 2002. Materia medica from insects. 137-145 pp. Shinilbooks, Seoul.
12 Cybulsky, M.I., J.W. Fries, A.J. Williams, P. Sultan, V.A. Davis, Jr. Gimbrone and T. Collin. 1991. Alternative splicing of human VCAM-1 in activated vascular endothelium. Am. J. Pathol. 138: 815-820.
13 Dettner, K. 1997. Inter and intraspecific transfer of toxic insect compound canthardidin. In Vertical Food Web Interactions. eds. by K. Dettner, G. Bauer, and W. Volkl. 115-145 pp. Springer, Berlin.
14 Geldof, A.A., S.C. Mastbergen, R.E. Henrar and G.T. Faircloth. 1999. Cytotoxicity and neurocytotoxicity of new marine anticancer agents evaluated using in vitro assays. Cancer Chemother. Pharmacol. 44: 312-318.   DOI   ScienceOn
15 Moilanen, E and H. Vapaatalo. 1995. Nitric oxide in inflammation and immune response. Ann. Med. 27: 359-367.   DOI   ScienceOn