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http://dx.doi.org/10.6114/jkood.2015.28.1.053

Effects of Gamijaungo on the burn mice model and the study of hematologic, pathologic and molecular mechanism  

Lee, Jong-Chul (Department of Ophthalmology, Otolaryngology and Dermatology, College of Korean Medicine, Gachon University)
Kim, Gyung-Jun (Department of Ophthalmology, Otolaryngology and Dermatology, College of Korean Medicine, Gachon University)
Publication Information
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology / v.28, no.1, 2015 , pp. 53-67 More about this Journal
Abstract
Objective: The aim of this study was to investigate the wound healing effect of herbal ointment, Gamijaungo, on the burn-induced model. Reports about Gamijaungo on the wound healing effect by local application in mice model or human study have published in the several domestic or internationally, but most are anecdotal and lack solid scientific evidence. Method: We observed the morphologic and histologic changes in the burn-induced mice model. we counted white blood cell and platelet changes. we confirmed VEGF, PI3K and pAkt protein expression by Western blot analysis. Result: In this study, we observed that Gamijaungo showed strong wound healing effects in the morphologic and histologic changes in the burn-induced mice model. Also we found that the significant changes of white blood cell and platelet changes by the treatment of Gamijaungo. In molecular mechanism, we got the strong positive effect by Gamijaungo treatment on angiogenesis, a key process in the formation of the granulation tissue during wound healing. Conclusion: These findings suggest the potential use of Gamijaungo as a therapeutic in thermal burn-induced skin injuries.
Keywords
wound healing; burn healing; Gamijaungo; jaungo; PI3K-Akt; VEGF;
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Times Cited By KSCI : 3  (Citation Analysis)
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