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http://dx.doi.org/10.6114/jkood.2015.28.1.032

An Experimental Study on the Effect of Angelica acutiloba Ethanol Extract on Hyaluronic Acid Synthesis  

Kang, Min-Seo (Dept. of Oriental Ophthalmology, Otolaryngology & Dermatology, College of Korean medicine, Semyung University)
Ha, Hun-Yong (Dept. of Natural Medicine Resources, Semyung University)
Kim, Hee-Taek (Dept. of Oriental Ophthalmology, Otolaryngology & Dermatology, College of Korean medicine, Semyung University)
Publication Information
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology / v.28, no.1, 2015 , pp. 32-40 More about this Journal
Abstract
Objectives : Hyaluronic acid(HA) is a mucopolysaccharide, occuring naturally in living organisms. It is one of the most hydrophilic molecules, so it has been known as being related to skin hydration and anti-aging. The purpose of this study is to examine the effects of Angelica acutiloba ethanol extract on hyaluronic acid synthesis. Methods : To determine cytotoxicity and hyaluronic acid synthase 2 gene expression, hyaluronic acid production in HaCaT cells, MTT assay and RT-PCR ELISA was used. Results : There was no cytotoxicity in $50{\mu}g/ml$ concentration Angelica acutiloba extract in MTT assay. Hyaluronic acid synthase 2(HAS2) gene expression was increased by all treated concentration Angelica acutiloba extract. Hyaluronic acid production was higher in $50{\mu}g/ml$ & $100{\mu}g/ml$ concentration Angelica acutiloba extract than control group. Conclusions : Hyaluronic acid production was increased by Angelica Acutiloba extracts. Therefore, We suggest that Angelica acutiloba can make a contribution to the moisturing effect on human skin. Conclusions : Hyaluronic acid production was increased by Angelica Acutiloba extracts. Therefore, We suggest that Angelica acutiloba can make a contribution to the moisturing effect on human skin.
Keywords
Angelica acutiloba; Hyaluronic acid; Hyaluronic acid synthesis; Moisturizing;
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Times Cited By KSCI : 4  (Citation Analysis)
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