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http://dx.doi.org/10.6114/jkood.2014.27.3.096

Effects of Glycyrrhiza uralensis Fisch (GUF) Extract on the Ovalbumin-Induced Allergid Asthma in Mice  

Jo, Eun-Hee (Dep. of Acupuncture and Moxibustion, Wonkwang University)
Jo, Il-Joo (Dep. of Herbology, Wonkwang University)
Park, Seong-Ju (Dep. of Herbology, Wonkwang University)
Jo, So-Hyun (Dep. of Oriental Ophthalmology and Otolaryngology and Dermatology, Wonkwang University)
Park, Min-Cheol (Dep. of Oriental Ophthalmology and Otolaryngology and Dermatology, Wonkwang University)
Publication Information
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology / v.27, no.3, 2014 , pp. 96-105 More about this Journal
Abstract
Objective : Glycyrrhiza uralensis Fisch (GUF) has been used as remedy of allergic diseases for a long time in Korea. In the present study, we investigated the anti-allergic effects of GUF on experimental allergic asthma mouse model using ovalbumin (OVA). Methods : BALB/c mice were sensitized and challenged with 100 ug of OVA and 1 mg of aluminum potassium sulfate of 0.2 ml phosphate-buffered saline (PBS) intraperitoneally on day 1 and 15. Mice were challenged on 3 consecutive days with 5% OVA and AHR was assessed 24 hrs after the last challenge. We examined total inflammatory cell number in bronchoaveloar lavage fluid (BALF), Th2-associated cytokine productions and lung histology. Results : GUF potently inhibited the development of airway hypersensitivity and also reduced the number of BAL cells during OVA-induced allergic asthma. GUF also inhibited cytokine productions such as IL-4, IL-13 in lung tissue. Furthermore, GUF treatment inhibited allergic airway inflammation. Conclusion : These results suggest that GUF may inhibit the production of IL-4, IL-13 and infiltration of inflammatory cell and be beneficial oriental medicine for allergic asthma.
Keywords
allergic asthma; ovalbumin; Th2 cytokines; Glycyrrhiza uralensis Fisch (GUF);
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