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http://dx.doi.org/10.6114/jkood.2014.27.3.084

Effects of Ephedra sinica (ES) Extract on the Ovalbumin-Induced Allergid Asthma in Mice  

Jo, Eun-Hee (Dep. of Acupuncture and Moxibustion, Wonkwang University)
Jo, Il-Joo (Dep. of Herbology, Wonkwang University)
Park, Seong-Ju (Dep. of Herbology, Wonkwang University)
Jo, So-Hyun (Dep. of Oriental Ophthalmology and Otolaryngology and Dermatology, Wonkwang University)
Park, Min-Cheol (Dep. of Oriental Ophthalmology and Otolaryngology and Dermatology, Wonkwang University)
Publication Information
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology / v.27, no.3, 2014 , pp. 84-95 More about this Journal
Abstract
Objective : Ephedra sinica (ES) has has been used as remedy of allergic diseases for a long time in Korea. In the present study, we investigated the anti-allergic effects of ES on experimental allergic asthma mouse model using ovalbumin (OVA). Methods : BALB/c mice were sensitized and challenged with 100 ug of OVA and 1 mg of aluminum potassium sulfate of 0.2 ml phosphate-buffered saline(PBS) intraperitoneally on day 1 and 15. mice were challenged on 3 consecutive days with 5% OVA and AHR was assessed 24 h after the last challenge. we examined the lung histology, airway hyper sensitivity, total inflammatory cell count in bronchoaveloar lavage fluid(BALF), Th2-associated cytokines production and IgE production. Results : ES potently inhibited the lung damage and the development of Penh. ES also reduced the number of BAL cells during OVA-induced allergic asthma. Furthermore, ES inhibited cytokines production such as IL-4, IL-13 productions, and IgE level of serum. Conclusion : These results suggest that ES may inhibit the production of IL-4, IL-13, IgE and infiltration of inflammatory cell and be beneficial oriental medicine for allergic asthma.
Keywords
allergic asthma; ovalbumin; Th2 cytokines; Ephedra sinica;
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